PMID: 9176882May 1, 1997Paper

Coronary heart disease and genetics in epidemiologist's view

Molecular Medicine Today
F CambienL Tiret

Abstract

We are just beginning to uncover the genetic determinants of coronary heart disease. The genotype-phenotype associations are complex as a consequence of pleiotropy, variation with age, selection owing to the high lethality of the disease, and interactions between genes and with environmental factors. Nevertheless, identification of the gene variants involved in the chronic and acute processes of coronary heart disease appears possible; this could considerably improve our understanding of the aetiology and mechanisms of this disease. Simultaneous analysis of several predisposing alleles should provide the means to identify high-risk individuals and to adapt therapeutic approaches to the genetic make-up of patients.

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Citations

Dec 12, 2001·European Journal of Clinical Investigation·R A AllenM Pirmohamed
Sep 25, 2002·Journal of Internal Medicine·S ZdravkovicU De Faire
Nov 28, 2002·European Journal of Heart Failure·Stefan-Martin HerrmannVera Regitz-Zagrosek
May 16, 2007·Comptes rendus biologies·Pierre Ducimetière, François Cambien
Mar 10, 2007·International Journal of Immunopathology and Pharmacology·I SbarsiM Cuccia
Feb 25, 2017·Journal of Clinical Laboratory Analysis·Elaheh KazemiMajid Ghayour-Mobarhan

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