Coronary heart disease is associated with regional grey matter volume loss: implications for cognitive function and behaviour

Internal Medicine Journal
O P AlmeidaLeon Flicker

Abstract

Coronary heart disease (CHD) has been associated with impaired cognition, but the mechanisms underlying these changes remain unclear. We designed this study to determine whether adults with CHD show regional brain losses of grey matter volume relative to controls. We used statistical parametric mapping (SPM5) to determine regional changes in grey matter volume of T(1)-weighted magnetic resonance images of 11 adults with prior history of myocardial infarction relative to seven healthy controls. All analyses were adjusted for total grey and white matter volume, age, sex and handedness. CHD participants showed a loss of grey matter volume in the left medial frontal lobe (including the cingulate), precentral and postcentral cortex, right temporal lobe and left middle temporal gyrus, and left precuneus and posterior cingulate. CHD is associated with loss of grey matter in various brain regions, including some that play a significant role in cognitive function and behaviour. The underlying causes of these regional brain changes remain to be determined.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Dec 24, 1997·The British Journal of Clinical Psychology·L Beardsall, F Huppert
Jan 31, 1998·The Annals of Thoracic Surgery·P K SmithL H Muhlbaier
Aug 10, 2002·Journal of Psychosomatic Research·Sibel Tekin, Jeffrey L Cummings
Apr 30, 2003·Journal of Applied Physiology·Mary A WooRonald M Harper
Feb 21, 2004·Nature Reviews. Neuroscience·Narender Ramnani, Adrian M Owen
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Mar 8, 2005·Cerebral Cortex·Yaakov SternRonald van Heertum
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Apr 26, 2007·Anesthesia and Analgesia·Brendan S SilbertPaul T Maruff
Sep 22, 2007·NeuroImage·Rosa Aurora Chávez-EakleCarlos Cruz-Fuentes

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Citations

Feb 3, 2012·European Heart Journal·Osvaldo P AlmeidaLeon Flicker
Feb 24, 2010·Clinics in Geriatric Medicine·Leon Flicker
Jul 22, 2010·Journal of the American Geriatrics Society·Walter SwardfagerKrista L Lanctôt
Feb 28, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Natalie KappusRobert Zivadinov
Jul 11, 2014·Journal of Geriatric Psychiatry and Neurology·Michael L AloscoLawrence H Sweet
Oct 15, 2008·Current Opinion in Psychiatry·Leon Flicker
Jan 13, 2016·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Jeffrey GaudetMichel Johnson
Oct 15, 2008·Current Opinion in Psychiatry

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