Coronary heart disease mortality and adjuvant tamoxifen therapy

Journal of the National Cancer Institute
J P CostantinoJ Dignam

Abstract

Data from randomized clinical trials in Scotland and Sweden testing the efficacy of tamoxifen therapy in patients with breast cancer have suggested that the drug may also reduce the risk of coronary heart disease. In view of these findings, we examined mortality from coronary heart disease among patients with early stage breast cancer who were enrolled in the National Surgical Adjuvant Breast and Bowel Project B-14 trial of tamoxifen therapy. Deaths occurring among women who were randomly assigned to 5 years of either tamoxifen or placebo in the first phase of the B-14 trial were reviewed to determine the cause. Three categories of heart disease-related death were defined: 1) death from a definite fatal myocardial infarction, 2) death from definite fatal coronary heart disease/possible myocardial infarction, and 3) death from possible fatal coronary heart disease. Comparisons of the findings by treatment group were made on the basis of average annual hazard (i.e., death) rates and the corresponding relative hazard of death. The average annual death rate from coronary heart disease was lower for patients who received tamoxifen than for patients who received placebo, but the difference was not statistically significant. There wer...Continue Reading

References

Jul 25, 1992·BMJ : British Medical Journal·J A DewarR A Wood
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J CuzickV Parsons
Apr 1, 1992·Statistics in Medicine·E L Korn, F J Dorey
Feb 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SaphnerR Gray
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J PowlesJ A McKinna
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J D BagdadeW Ryan
Sep 1, 1990·The Australian and New Zealand Journal of Surgery·D Ingram
Oct 1, 1988·British Journal of Cancer·P F BruningW J Nooyen
Dec 1, 1988·Breast Cancer Research and Treatment·G BertelliR Rosso
Apr 1, 1996·Nature Medicine·D J Grainger, J C Metcalfe

❮ Previous
Next ❯

Citations

May 11, 2010·Amino Acids·Aaron K HolleyDaret K St Clair
Jan 11, 2007·Breast Cancer Research and Treatment·Sonal Gandhi, Sunil Verma
Jan 7, 2010·Breast Cancer Research and Treatment·Ateeq AhmadImran Ahmad
Nov 2, 2004·Familial Cancer·Murray Joseph Casey, Chhanda Bewtra
Apr 11, 2003·Current Treatment Options in Cardiovascular Medicine·Svati H. Shah, Karen P. Alexander
Mar 5, 2004·Surgical Oncology·J M Dixon
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·E Barrett-ConnorP W Anderson
Feb 13, 2001·Primary Care Update for Ob/Gyns·M J. Sexton, R B. Gherman
Dec 8, 2000·Breast Cancer Research and Treatment·H JoensuuR Valavaara
Oct 27, 2001·The Breast Journal·G MaugeriF Nardo
Sep 29, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. H. N. UgwumaduP. Neven
Dec 23, 2003·Journal of General Internal Medicine·R Scott BraithwaiteNananda F Col
Nov 26, 1998·The New England Journal of Medicine·C K Osborne
Jun 13, 2003·The New England Journal of Medicine·Ian E Smith, Mitch Dowsett
Jun 4, 1997·Journal of the National Cancer Institute·V C Jordan
Jul 17, 1998·Journal of the National Cancer Institute·V C Jordan
Nov 3, 2005·Journal of the National Cancer Institute·Bo NordenskjöldJohn Carstensen
Jun 10, 2009·Mutagenesis·Karen Brown
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·P Neven, I Vergote
Jul 13, 2000·Obstetrical & Gynecological Survey·V L BakerR B Jaffe
Nov 16, 2004·Gynecologic and Obstetric Investigation·Yasuo HozumiHideo Nagai
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yanfei L MaMasahiko Sato
Apr 4, 2002·Drugs & Aging·Carol J Fabian, Bruce F Kimler
Aug 30, 2000·Ugeskrift for laeger·E F Eriksen
Mar 22, 2002·The Lancet Oncology·V C Jordan
Nov 21, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G von MinckwitzM Kaufmann
Nov 9, 2010·Annual Review of Medicine·Simak AliR Charles Coombes
Oct 2, 2003·Expert Opinion on Investigational Drugs·Jun R Chiong, Alan B Miller
Aug 9, 2003·Expert Opinion on Drug Safety·Karen Brown
Mar 28, 2008·The Breast : Official Journal of the European Society of Mastology·Rowan T Chlebowski
Dec 8, 2006·Cancer Letters·Claudia Andreetta, Ian Smith
Oct 3, 2003·Journal of Thrombosis and Haemostasis : JTH·B BonanniA Decensi
May 11, 2004·Preventive Cardiology·Radhika NandurAmparo C Villablanca
Mar 25, 1999·Current Problems in Surgery·M MorrowL J Pierce
Oct 11, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsung-Lin YangHsin-Bang Leu
Aug 25, 2001·American Journal of Obstetrics and Gynecology·M L Gass, M B Taylor
Apr 17, 2001·American Journal of Obstetrics and Gynecology·R A Wild, S E Reis
May 6, 2014·The Breast : Official Journal of the European Society of Mastology·Felipe AdesEvandro de Azambuja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.