PMID: 6104171Jun 28, 1980Paper

Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study

Lancet
J H FullerH Keen

Abstract

In the Whitehall Study of 18,403 male civil servants aged 40--64 years, 7 1/2 year coronary-heart-disease (CHD) mortality has been examined in relation to blood-sugar concentration 2 h after a 50 g oral glucose load. CHD mortality was approximately doubled for subjects with inpaired glucose tolerance (IGT), defined as a blood-sugar above the 95th centile (greater than or equal to 96 mg/dl). There was no trend of CHD mortality with blood-sugar below the 95th centile. Within the IGT group, age, systolic blood-pressure, and ECG abnormality (Whitehall criteria) were significantly predictive of subsequent CHD mortality. These findings are relevant to discussions on the criteria for diabetes which include the definition of an IGT category with increased risk of large-vessel disease, but without the high risk of small-vessel disease as occurs in diabetes mellitus.

References

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Sep 1, 1979·Diabetologia·A G Cudworth
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Citations

Feb 1, 1990·Diabetes/metabolism Reviews·F L Dunn
Mar 1, 1990·Diabetes/metabolism Reviews·P ZimmetH King
Dec 1, 1990·Diabetes/metabolism Reviews·K L RamaiyaK G Alberti
Sep 1, 1982·Diabetologia·W J Mutch, J M Stowers
Jan 1, 1985·Diabetologia·K FalholtL G Heding
Nov 1, 1983·Diabetologia
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Jan 1, 1992·European Journal of Clinical Pharmacology·F PasanisiM Mancini
Oct 12, 2012·Diabetologia·K A M Jandeleit-Dahm, S P Gray
Sep 27, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Selim AyhanMehmet Yazici
Jul 8, 2008·Reviews in Endocrine & Metabolic Disorders·Ramachandran Ambady, Snehalatha Chamukuttan
Mar 6, 2010·Reviews in Endocrine & Metabolic Disorders·Matteo AnselminoLars Rydén
Aug 13, 2003·Current Atherosclerosis Reports·Gerald M Reaven
Jan 1, 1983·Preventive Medicine·G Rose
Jul 1, 1995·Diabetes Research and Clinical Practice·M SekiyaT Kamada
Aug 1, 1996·Diabetes Research and Clinical Practice·Q QiaoS L Kivelä

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