Coronary heart disease risk in patients with stroke or transient ischemic attack and no known coronary heart disease: findings from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial

Stroke; a Journal of Cerebral Circulation
Pierre AmarencoStroke Prevention by Aggressive Reduction in Cholesterol Levels Investigators

Abstract

Noncoronary forms of atherosclerosis (including transient ischemic attacks or stroke of carotid origin or >50% stenosis of the carotid artery) are associated with a 10-year vascular risk of >20% and are considered as a coronary heart disease (CHD) -risk equivalent from the standpoint of lipid management. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial included patients with stroke or transient ischemic attack and no known CHD regardless of the presence of carotid atherosclerosis. We evaluated the risk of developing clinically recognized CHD in SPARCL patients. A total of 4731 patients (mean age, 63 years) was randomized to 80 mg/day atorvastatin placebo. The rates of major coronary event, any CHD event, and any revascularization procedure were evaluated. After 4.9 years of follow-up, the risks of a major coronary event and of any CHD end point in the placebo group were 5.1% and 8.6%, respectively. The rate of outcome of stroke decreased over time, whereas the major coronary event rate was stable. Relative to those having a large vessel-related stroke at baseline, those having a transient ischemic attack, hemorrhagic stroke, small vessel stroke, or a stroke of unknown cause had similar absolute...Continue Reading

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Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Fernando Gongora-RiveraPierre Amarenco

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Citations

Apr 22, 2010·Vascular Health and Risk Management·Branko N HuisaJustin A Zivin
Apr 9, 2010·Current Opinion in Cardiology·Vasilios G AthyrosDimitri P Mikhailidis
Dec 15, 2010·Current Opinion in Neurology·Aine Merwick, Peter J Kelly
Jan 24, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Francisco PurroyGerard Piñol-Ripoll
Oct 11, 2014·Acta Neurologica Scandinavica·M B VilanovaF Purroy
Aug 5, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Emre KumralMehmet Orman
Dec 12, 2012·Atherosclerosis·Fisnik JashariMichael Y Henein
Mar 1, 2015·Journal of Neurointerventional Surgery·P BhogalH L D Makalanda
Apr 20, 2013·Stroke; a Journal of Cerebral Circulation·Pierre AmarencoPhilippe Gabriel Steg
Sep 6, 2012·Stroke; a Journal of Cerebral Circulation·Amytis TowfighiBruce Ovbiagele
May 30, 2019·Acta Neurologica Scandinavica·Tiberiu A PanaUNKNOWN Norfolk and Norwich Stroke and TIA Register Steering Committee Collaborators
Nov 2, 2019·Scandinavian Journal of Caring Sciences·Pramila GaudelAnja Rantanen
Dec 30, 2020·Journal of the American Heart Association·Keon-Joo LeeUNKNOWN CRCS‐K Registry Investigators
Jan 23, 2021·The Cochrane Database of Systematic Reviews·Muhammad Ismail ShawishJames M Wright
May 25, 2021·Topics in Stroke Rehabilitation·Esra Mustafa, Yesim Kurtais Aytür

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