Coronary hemodynamics during reperfusion following acute coronary ligation in dogs.

American Heart Journal
P E ParkerA G Williams

Abstract

The coronary hemodynamic effects of re-establishing blood flow to ischemic myocardium and the regional distribution of myocardial flow during reperfusion were studied in anesthetized open-chest dogs. A large portion of the left ventricular wall was rendered ischemic by occlusion of the left anterior descending coronary artery for 2 hours. During reperfusion of the LAD, coronary resistance in the reperfused vasculature increased progressively for the first 3 hours, while resistance in the intact LC vasculature was unchanged. Minimal resistances in the reperfused vascular bed, calculated from mean aortic pressure and peak coronary reactive hyperemic blood flow following a 90 sec. LAD occlusion, were elevated significantly during reperfusion. The increased minimal resistance values, which reflect the passive physical component of resistance, indicate structural changes in the reperfused vascular bed which were evident shortly after the initiation of reperfusion and persisted throughout the experimental period. Coronary resistances (RH) in the reperfused (LAD) and intact (LC) vasculatures during the reactive hyperemia following 10 sec. coronary occlusions were evaluated. During reperfusion, RH in the reperfused vasculature increase...Continue Reading

Citations

Jul 1, 1980·Basic Research in Cardiology·M HofmannW Schaper
Sep 1, 1982·Clinical and Experimental Pharmacology & Physiology·G J CrystalF A Bashour
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Fei TianLevent M Akyürek
Feb 7, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sandro GelsominoRoberto Lorusso
Jul 31, 2007·Journal of Cardiac Surgery·Matthias SiepeFriedhelm Beyersdorf

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