PMID: 9535151Apr 16, 1998Paper

Coronary hemodynamics in aging spontaneously hypertensive and normotensive Wistar-Kyoto rats

Journal of Hypertension
D SusicE D Frohlich

Abstract

To delineate hypertension-related and age-related changes in coronary hemodynamics and to assess the role of myocardial (i.e. left ventricular) hypertrophy and cardiac fibrosis in inducing progressive deterioration of coronary flow reserve associated both with hypertension and with aging. Systemic and coronary hemodynamics (using radionuclide-labeled microspheres), right ventricular, left ventricular, and aortic mass indexes, and ventricular hydroxyproline concentrations (an estimate of collagen) in normotensive Wistar-Kyoto and spontaneously hypertensive rats aged 22, 35, and 65 weeks were determined. Spontaneously hypertensive rats of all ages had greater left ventricular and aortic masses, greater collagen concentrations in both ventricles, a lower coronary flow reserve, and greater minimal coronary vascular resistance after administration of dipyridamole than did Wistar-Kyoto rats. Despite spontaneously hypertensive rats having only left ventricular hypertrophy, coronary hemodynamics were impaired to the same extent in both ventricles. Progressive increases in myocardial collagen concentration, decreases in coronary flow reserve, and increases in minimal coronary vascular resistance were observed in rats of both strains wit...Continue Reading

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Citations

Nov 4, 2000·Current Hypertension Reports·D Susic, E D Frohlich
Sep 19, 2003·Journal of the American College of Cardiology·Dinko SusicEdward D Frohlich
Jan 1, 1983·Journal of the American College of Cardiology·E D Frohlich
Nov 7, 1999·Journal of the American College of Cardiology·E D Frohlich
Jan 29, 2008·Nature Clinical Practice. Cardiovascular Medicine·Dinko Susic, Edward D Frohlich
Jan 9, 2010·Vascular Health and Risk Management·Andrew S LevyJames W E Rush
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·Jasmina Varagic, Edward D Frohlich
Nov 4, 2000·Expert Opinion on Investigational Drugs·D Susic
Feb 13, 2016·Genetic Testing and Molecular Biomarkers·Cigdem Yuce KahramanAbdulgani Tatar
Sep 22, 2012·Journal of the American Society of Hypertension : JASH·Dinko SusicEdward D Frohlich
Jun 28, 2011·Mechanisms of Ageing and Development·Vanda PintoPatrício Soares-da-Silva
Oct 16, 2002·Biochimica Et Biophysica Acta·N D VaziriS Shahinfar
Mar 26, 2013·Mechanisms of Ageing and Development·Edina A WapplerGyörgy L Nádasy
Nov 24, 2011·Heart Failure Clinics·Edward D Frohlich, Dinko Susic
Oct 8, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Dinko SusicEdward D Frohlich
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E D Frohlich
Jun 26, 2004·Current Opinion in Cardiology·Dinko SusicEdward D Frohlich
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Edward D Frohlich
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Edward D Frohlich, Jasmina Varagic
Feb 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dinko SusicEdward D Frohlich
Nov 13, 2001·Current Opinion in Cardiology·J VaragicE Frohlich
Feb 8, 2003·Hypertension·Michaela KozàkovàCarlo Palombo
Jul 14, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·J VaragicE D Frohlich
Aug 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Dinko SusicEdward D Frohlich

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