Coronary high-signal-intensity plaques on T1 -weighted magnetic resonance imaging reflect intraplaque hemorrhage

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Yasuyoshi KuroiwaYujiro Asada

Abstract

Coronary high-signal-intensity plaques (HIPs) detected by T1-weighted magnetic resonance imaging are associated with future cardiovascular events. This study aimed to identify pathological findings reflecting HIPs in coronary arteries obtained from autopsy cases. Formalin-fixed hearts were imaged with noncontrast T1-weighted imaging with a 1.5-T magnetic resonance system. We defined HIPs or non-HIPs as a coronary plaque to myocardial signal intensity ratio (PMR) of ≥1.4 or <1.4, respectively. We found HIPs in 4 of 37 (10.8%) hearts and analyzed 7 hearts in detail. The corresponding sections to HIPs (n=11) or non-HIPs (n=25) were histologically and immunohistochemically analyzed. We calculated the T1 relaxation time of human venous blood in vitro. Plaque and necrotic core areas, and the frequency of intraplaque hemorrhage in HIPs were significantly larger/higher than those in non-HIPs. HIPs were immunopositive for CD68 (11/11), glycophorin A (10/11), and fibrin (11/11). Glycophorin-A-, matrix metalloprotease 9 (MMP9)-, and tissue factor-immunopositive areas were larger in HIPs than in non-HIPs. The PMR was positively correlated with glycophorin-A-, fibrin-, MMP9-, and tissue factor-immunopositive areas. Blood coagulation shorten...Continue Reading

Citations

Jan 17, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hayato HosodaSatoshi Yasuda
Dec 11, 2020·Journal of Atherosclerosis and Thrombosis·Masanori NishimuraYujiro Asada
Mar 7, 2021·Biomedicines·Kristina AndelovicAlma Zernecke
Nov 19, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Akiyuki KotokuHidefumi Mimura

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