Abstract
The aim of this study was to explore the evolution of coronary lesions which had repeated physiologic evaluation by FFR as an endpoint, describe the clinical significance of longitudinal FFR change (ΔFFR=FFRfollow-up-FFRbaseline) and its correlation with angiographic indices, and identify predictors of FFRfollow-up. A retrospective, single-centre analysis of 414 stenoses (331 patients) with consecutive FFR measurements at least six months apart was performed (median time interval: 24 [17, 37] months). The change in percent diameter stenosis was 2% (-5%, 11%). FFR values at baseline and follow-up were 0.86 (0.82, 0.90) and 0.83 (0.79, 0.90), respectively (<0.0001). The median ΔFFR was -0.007 (-0.028, 0.010) per year. Worsening FFR (ΔFFR <-0.05) was observed in 105 (25%) stenoses, stable FFR (-0.05 ≤ΔFFR ≤0.05) in 276 (67%) and improving FFR (ΔFFR >0.05) in 33 (8%) stenoses. The number of haemodynamically significant stenoses (FFR ≤0.80) was higher at follow-up compared to baseline (33% versus 17%, p<0.0001); ΔFFR correlated weakly with delta diameter stenosis (Δ%DS, ρ=-0.111, p=0.024). In mixed effects repeated measures analysis, only lesion location had an independent correlation with FFR values after adjusting for multiple con...Continue Reading
References
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN REVERSAL Investigators
Apr 22, 2006·BMJ : British Medical Journal·Jo C DumvilleCatherine E Hewitt
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Dec 7, 2007·International Journal of Cardiology·Narbeh MelikianBernard De Bruyne
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
Jun 12, 2010·Journal of the American College of Cardiology·Nico H J PijlsUNKNOWN FAME Study Investigators
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
May 15, 2012·Journal of the American College of Cardiology·Manesh R PatelR Parker Ward
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Nov 21, 2012·Circulation·Stephan D FihnUNKNOWN American College of Cardiology Foundation
Jan 8, 2014·European Heart Journal·Philippe Kolh
Mar 20, 2014·European Heart Journal·Gabor TothBernard De Bruyne
Sep 2, 2014·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Oct 18, 2014·Journal of the American College of Cardiology·Nils P JohnsonK Lance Gould
Oct 23, 2014·European Heart Journal·Jeremiah P DeptaRichard G Bach
Jun 5, 2015·European Heart Journal·Masanori TaniwakiLorenz Räber
Jul 25, 2015·JACC. Cardiovascular Interventions·Nils P JohnsonK Lance Gould
Sep 25, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Maria E RomeroRenu Virmani
Sep 25, 2015·European Heart Journal·Frederik M ZimmermannNico H J Pijls
Oct 28, 2015·Nature Reviews. Cardiology·Kazuyuki YahagiRenu Virmani
May 27, 2016·Nature Reviews. Cardiology·Marc R DweckDaniel Berman
Aug 16, 2016·Journal of the American College of Cardiology·Gabor G TothBernard De Bruyne
Nov 26, 2016·Journal of the American College of Cardiology·Emanuele BarbatoBernard De Bruyne
Citations
Feb 23, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yuichi SaitoUNKNOWN FANTOM II Clinical Investigators
Jul 25, 2019·Journal of Clinical Medicine·Iginio ColaioriCarmine Morisco
Oct 20, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christopher M CookJustin E Davies