Coronary ligation-reperfusion arrhythmia models in anesthetized rats and isolated perfused rat hearts concentration-effect relationships of lidocaine

Journal of Pharmacological Methods
T UematsuF Follath

Abstract

A comparative study of two arrhythmia models was carried out using coronary ligation and reperfusion in anesthetized rats and in isolated rat hearts. Both models allowed evaluation of the concentration-effect relationships of lidocaine as an antiarrhythmic agent. The average free plasma-water concentration that reduced the incidence of ventricular fibrillation by 50% was comparable in both models: 1.9 mg/liter in vivo and 2.1 mg/liter in vitro, respectively. In isolated rat hearts significantly higher concentrations were required for 50% reduction of ventricular tachycardia than for the suppression of ventricular fibrillation (2.9 +/- 0.13 versus 2.1 +/- 0.11 mg/liter, p less than 0.05). The good agreement between effective lidocaine concentrations in vivo and in vitro suggests that the isolated rat heart preparation is suitable for the quantitative assessment of drug effects on occlusion-reperfusion arrhythmias. A better reproducibility and easier control of drug concentrations are the advantages of the in vitro model.

Citations

Oct 16, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Jacek SapaKatarzyna Kulig
Jul 2, 2003·European Journal of Medicinal Chemistry·Katarzyna Kieć-KononowiczMałgorzata Zygmunt
Mar 21, 2001·Journal of Pharmacological and Toxicological Methods·A R Kompa, R J Summers

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