Coronary Microembolization with Normal Epicardial Coronary Arteries and No Visible Infarcts on Nitrobluetetrazolium Chloride-Stained Specimens: Evaluation with Cardiac Magnetic Resonance Imaging in a Swine Model

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Hang JinMeng-Su Zeng

Abstract

To assess magnetic resonance imaging (MRI) features of coronary microembolization in a swine model induced by small-sized microemboli, which may cause microinfarcts invisible to the naked eye. Eleven pigs underwent intracoronary injection of small-sized microspheres (42 µm) and catheter coronary angiography was obtained before and after microembolization. Cardiac MRI and measurement of cardiac troponin T (cTnT) were performed at baseline, 6 hours, and 1 week after microembolization. Postmortem evaluation was performed after completion of the imaging studies. Coronary angiography pre- and post-microembolization revealed normal epicardial coronary arteries. Systolic wall thickening of the microembolized regions decreased significantly from 42.6 ± 2.0% at baseline to 20.3 ± 2.3% at 6 hours and 31.5 ± 2.1% at 1 week after coronary microembolization (p < 0.001 for both). First-pass perfusion defect was visualized at 6 hours but the extent was largely decreased at 1 week. Delayed contrast enhancement MRI (DE-MRI) demonstrated hyperenhancement within the target area at 6 hours but not at 1 week. The microinfarcts on gross specimen stained with nitrobluetetrazolium chloride were invisible to the naked eye and only detectable microscopi...Continue Reading

References

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H DörgeG Heusch
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanAnthony H Aletras
Dec 6, 2002·Current Opinion in Cardiology·Michael PoonZahi Fayad
Mar 6, 2004·Postgraduate Medicine·Robert L Litchfield
Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Oct 24, 2006·Radiology·J Paul FinnGerhard Laub
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcus CarlssonMaythem Saeed
Mar 24, 2010·AJR. American Journal of Roentgenology·Hang JinRen-Chen Li
Apr 6, 2011·Scandinavian Cardiovascular Journal : SCJ·Marcus CarlssonMaythem Saeed
Nov 2, 2011·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hong YunShan Yang
Oct 16, 2012·The International Journal of Cardiovascular Imaging·Maythem SaeedMark W Wilson
Aug 19, 2014·Journal of Cellular and Molecular Medicine·Zhang-Wei ChenJun-Bo Ge

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Citations

Jul 11, 2021·Biochemical and Biophysical Research Communications·Man-Lu FanXiao-Hu Chen

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Methods Mentioned

BETA
imaging technique

Software Mentioned

DE
Segment
MRI
Argus

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