Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease

Cardiovascular Diabetology
Jaskanwal D SaraAmir Lerman

Abstract

Patients with type 2 diabetes mellitus are at an increased risk of adverse cardiovascular events compared to those without diabetes. The timing, relative to disease onset, and degree of glycemic control that reduces the risk of adverse cardiovascular events remains uncertain. Coronary microvascular dysfunction is prevalent in patients with type 2 diabetes mellitus and is linked to adverse cardiovascular events. We assessed the association between endothelial-dependent and endothelial-independent coronary microvascular dysfunction and glycemic control in patients presenting with chest pain and nonobstructive coronary disease at angiography. Patients presenting with chest pain and found to have non-obstructive CAD (stenosis < 40%) at angiography underwent an invasive assessment of endothelial-independent and endothelial -dependent microvascular function. Endothelial-independent microvascular function was assessed by comparing the coronary flow velocity, measured using a Doppler guidewire, in response to intracoronary infusion of adenosine to calculate the coronary flow reserve ratio in response to adenosine (CFRAdn Ratio). A CFRAdn Ratio ≤ 2.5 was considered abnormal. Endothelial-dependent microvascular function was assessed by m...Continue Reading

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Citations

Feb 20, 2020·Journal of Women's Health·Hena PatelAnnabelle Santos Volgman
Aug 1, 2020·Frontiers in Physiology·Kaihao WangAnthony Martin Gerdes
Oct 26, 2020·Cardiovascular Diabetology·Yuanyuan ZhangXianhui Qin
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Dec 23, 2020·Advances in Therapy·Kevin ChengRanil De Silva
Feb 27, 2021·Cardiovascular Endocrinology & Metabolism·Aish SinhaDivaka Perera
Aug 20, 2021·Therapeutic Advances in Endocrinology and Metabolism·Jian L YeoGaurav S Gulsin
Dec 24, 2021·European Journal of Clinical Investigation·George Markousis-MavrogenisSophie I Mavrogeni

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