Coronary plaque characteristics in computed tomography and 2-year outcomes: The PREDICT study

Journal of Cardiovascular Computed Tomography
Hideya YamamotoPREDICT Investigators

Abstract

Coronary computed tomography angiography (CCTA) not only provides information regarding luminal stenoses but also allows for visualization of mural atheromatous changes (coronary plaques). We sought to elucidate whether plaques seen on CCTA enable prediction of 2-year outcomes in patients with suspected and known coronary artery disease (CAD). Of 3015 patients who underwent CCTA, the images and 2-year clinical courses of 2802 patients were independently analyzed. The primary endpoint was the composite of all-cause death and acute coronary syndrome. During the 2-year observation period, 49 (1.7%) patients developed the primary outcome. The 2-year rates of the primary outcome in the normal (n = 515, no mural lesions), calcium (n = 654, calcified lesion alone), and plaque groups (n = 1633, presence of noncalcified or partially calcified plaques) were 0.2%, 2.0%, and 2.1%, respectively (P = 0.0028). Adverse plaque features such as low attenuation, positive remodeling, spotty calcification, and the napkin-ring sign (low-attenuation core with a higher-attenuation rim) were assessed by an independent core laboratory. Stepwise multivariate Cox proportional hazard analysis showed that a plaque with two or more characteristics (adjusted ...Continue Reading

Citations

Nov 30, 2018·Cardiology in Review·Mohammed Hasan KhanWilliam H Frishman
Nov 18, 2020·The International Journal of Cardiovascular Imaging·Breda HennesseyJavier Escaned
Aug 23, 2020·Journal of Cardiovascular Computed Tomography·Hideya YamamotoSachio Kuribayashi
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group

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