Coronary Plaque Characteristics in Patients With Diabetes Mellitus Who Presented With Acute Coronary Syndromes

Journal of the American Heart Association
Tomoyo SugiyamaIk-Kyung Jang

Abstract

Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. A total of 322 patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of the culprit lesion were included. Culprit plaque characteristics were compared between patients with DM (n=95) and those without DM (n=227). In the subgroup of 250 patients in whom sufficient length of nonculprit region in the culprit vessel was imaged by optical coherence tomography, the characteristics of nonculprit plaques were also evaluated. Patients with DM had a higher prevalence of lipid-rich plaque (58.9% versus 44.9%, P=0.030) and macrophage accumulation (60.0% versus 44.9%, P=0.019) in the culprit lesion compared with patients without DM. The prevalence of plaque rupture (33.7% versus 30.4%, P=0.896) and plaque erosion (21.1% versus 22.0%, P=0.458) was similar. In the nonculprit lesions, the DM group had greater maximal lipid arc (248.9°±83.9° versus 179.9°±58.3°, P=0.006), thinner fibrous cap thickness (103.3±56.2 μm versus 140.7±70.0 μm, P=0.013), and a higher prevalence o...Continue Reading

Associated Clinical Trials

References

May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Jul 27, 2002·Journal of the American College of Cardiology·Jeffrey L CarsonStephen H Schneider
Dec 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew A AllisonC Michael Wright
May 15, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Allen P BurkeRenu Virmani
Sep 26, 2006·American Heart Journal·Teruyoshi KumeKiyoshi Yoshida
Jul 19, 2008·Journal of the American College of Cardiology·Stephen J NichollsSteven E Nissen
Apr 10, 2009·JACC. Cardiovascular Imaging·Young Joon HongJung Chaee Kang
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Mar 17, 2012·Journal of the American College of Cardiology·Guillermo J TearneyUNKNOWN International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT)
Dec 21, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Masashi FukunagaTohru Masuyama
May 4, 2013·European Heart Journal·Francesco PaneniFrancesco Cosentino
Jul 15, 2015·Circulation. Cardiovascular Interventions·Sripal BangaloreEdward L Hannan
Jan 9, 2016·Circulation. Cardiovascular Imaging·Daniel S OngIk-Kyung Jang
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Rocco VergalloIk-Kyung Jang
Dec 3, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazuyuki YahagiRenu Virmani

❮ Previous
Next ❯

Citations

Oct 28, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi OkamotoShiro Uemura
May 1, 2021·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Salman BhatUmesh C Sharma
Apr 24, 2021·World Journal of Diabetes·Jake RajbhandariJoseph M Pappachan
Jul 9, 2021·Frontiers in Endocrinology·Vinay Singh TanwarRama Natarajan

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT01110538

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.