Coronary reserve of high- and low-flow regions in the dog heart left ventricle

Circulation
R LoncarA Deussen

Abstract

Left ventricular myocardial blood flow is spatially heterogeneous. The hypothesis we tested was whether myocardial areas with a steady-state flow <0.5 times mean flow are underperfused and areas with flow > 1.5 times mean flow are overperfused. In anesthetized beagle dogs (n=10), the relationship between local blood flow versus S-adenosylhomocysteine (SAH) concentration, a measure of the free intracellular adenosine concentration, and lactate, a measure of the myocardial NADH/NAD+ ratio, were determined under control conditions and after coronary constriction. Control local myocardial blood flow was 0.99+/-0.46 mL x min(-1) x g(-1), with a coefficient of variation of 0.36+/-0.12 (n=256 per heart; sample wet mass, 125+/-30 mg). Tissue concentrations of SAH (3.4+/-2.5 nmol/g) and lactate (1.88+/-0.80 micromol/g) were not elevated in low-flow samples. However, after coronary artery constriction, poststenotic blood flow decreased from 1.00+/-0.27 to 0.49+/-0.22 mL x min(-1) x g(-1) (P<0.04), with significant correlation between local SAH and flow (r=-0.59) and lactate and flow (r = -0.50). Although nearly all samples from control high-flow regions showed increased SAH concentrations if relative flow after stenosis was <1.0, control...Continue Reading

References

Dec 1, 1977·American Heart Journal·M L MarcusF M Abboud
Apr 29, 1975·Pflügers Archiv : European journal of physiology·B LösseN Niederle
Apr 1, 1991·The American Journal of Physiology·R T SmolenskiA Deussen
Jan 1, 1989·Journal of Molecular and Cellular Cardiology·R J WiesnerM K Grieshaber
Mar 1, 1987·Progress in Cardiovascular Diseases·R A Olsson, R Bünger
Jan 1, 1983·Physiological Reviews·E O Feigl
Jul 1, 1996·Pflügers Archiv : European journal of physiology·M SonntagJürgen Schrader
Jul 1, 1996·Pflügers Archiv : European journal of physiology·A DeussenJürgen Schrader
Feb 1, 1997·Pflügers Archiv : European journal of physiology·A Deussen

Citations

Nov 24, 1999·The American Journal of Cardiology·O T RaitakariJ Hartiala
Aug 24, 2013·Nature Reviews. Immunology·Rama KhokhaAshley Weiss
Jan 28, 2003·Journal of Cardiovascular Pharmacology·Coert Jozef ZuurbierCan Ince
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·A DeussenSebastian N Stehr
Oct 19, 2011·Journal of Molecular and Cellular Cardiology·A DeussenWilliam Chilian
Jan 7, 2004·Acta Physiologica Scandinavica·R LoncarA Deussen
Jan 1, 2010·Therapeutic Advances in Cardiovascular Disease·Catharina NesselmannGustav Steinhoff
Feb 2, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Axel MeissnerGunnar Plehn
Nov 16, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Ulrich K M Decking
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tim LaussmannUlrich K M Decking
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·U SchwankeJ D Schipke
Apr 2, 2002·Cardiovascular Research·Matthijs F M van OosterhoutFrits W Prinzen
Sep 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·D J AldersJohannes H G M van Beek
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G SambucetiA L'Abbate
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T MatsumotoF Kajiya
Nov 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Tada YipintsoiJames B Bassingthwaighte
Feb 24, 2004·Annual Review of Physiology·Matthew L Williams, Walter J Koch
Feb 14, 2002·Journal of Applied Physiology·Gösta BerlinRobert D Woodson
Oct 12, 1999·The American Journal of Physiology·J H van BeekJ Bussemaker

Related Concepts

Metazoa
Coronary Circulation
Coronary Heart Disease
Canis familiaris
Osmolality
S-Adenosylhomocysteine
Left Ventricular Function
Ammonium lactate

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