PMID: 22340344Feb 22, 2012Paper

Coronary spasm, a pathogenic trigger of vulnerable plaque rupture

Chinese Medical Journal
Li-Xin WangLi-Jie Zhang

Abstract

This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. These reports from major review on coronary artery spasm. and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

Journal of the Royal Society of Medicine
D R Richmond
Mayo Clinic Proceedings
H B Burchell
Duodecim; lääketieteellinen aikakauskirja
M Ikäheimo
© 2022 Meta ULC. All rights reserved