Coronary stenting and inflammation: implications for further surgical and medical treatment

The Annals of Thoracic Surgery
Walter J Gomes, Enio Buffolo

Abstract

The introduction of percutaneous coronary interventions (PCI) with stent implant has substantially shifted the treatment of coronary artery disease. The current approach to coronary artery disease treatment includes first-choice PCI in selected subgroups; and once this therapy fails, frequently the patient is referred for coronary artery bypass graft surgery. However, evidence of chronic inflammatory reaction and endothelial dysfunction after PCI has been emerging and that might be interfering with patient outcome when surgical or medical treatments are subsequently required. The clinical significance of these complications after PCI, herein examined, has been less studied and needs better assessment. Also, the premise that coronary artery bypass graft surgery can safely be performed in patients with coronary stenting failure may not hold true, as graft patency might be adversely affected. Furthermore, the superimposed inflammatory reaction may blunt the efficacy of medical treatment.

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Citations

Apr 5, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nikolaos BonarosThomas Schachner
Jan 19, 2008·Artificial Organs·Shunya ShindoMasahiko Matsumoto
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Mar 31, 2009·The Journal of Thoracic and Cardiovascular Surgery·Parwis MassoudyHeinz Jakob
Mar 17, 2015·The Journal of Thoracic and Cardiovascular Surgery·Victor NauffalRobert H Habib
Jul 30, 2010·The Annals of Thoracic Surgery·Vladimiro L VidaGiovanni Stellin
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May 16, 2018·General Thoracic and Cardiovascular Surgery·Shin YajimaYoshiki Sawa
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Anqi SunJun Wen

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