Coronary stents with inducible VEGF/HGF-secreting UCB-MSCs reduced restenosis and increased re-endothelialization in a swine model.

Experimental & Molecular Medicine
Hyun-Kyung ChangJe-Yoel Cho

Abstract

Atherosclerotic plaques within the vasculature may eventually lead to heart failure. Currently, cardiac stenting is the most effective and least invasive approach to treat this disease. However, in-stent restenosis is a complex chronic side effect of stenting treatment. This study used coronary stents coated with stem cells secreting angiogenic growth factors via an inducible genome-editing system to reduce stent restenosis and induce re-endothelialization within the artery. The characteristics of the cells and their adhesion properties on the stents were confirmed, and the stents were transplanted into a swine model to evaluate restenosis and the potential therapeutic use of stents with stem cells. Restenosis was evaluated using optical coherence tomography (OCT), microcomputed tomography (mCT) and angiography, and re-endothelialization was evaluated by immunostaining after cardiac stent treatment. Compared to a bare metal stent (BMS) or a parental umbilical cord blood-derived mesenchymal stem cell (UCB-MSC)-coated stent, the stents with stem cells capable of the controlled release of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) successfully reduced restenosis within the stent and induced natura...Continue Reading

References

May 22, 2004·Stem Cells·Joachim OswaldCarsten Werner
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Dec 17, 2004·Pharmacological Reviews·Ann HoebenErnst A De Bruijn
May 3, 2006·The American Journal of Pathology·Jing-Lin XiaYouhua Liu
Feb 24, 2007·Vascular Health and Risk Management·Thein Htay, Ming W Liu
Jun 23, 2007·Current Pharmaceutical Design·D VersariA Lerman
Jan 3, 2008·Nature Materials·J Herbert Waite
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Zhenhua ZhouChuhong Zhu
Mar 14, 2009·Biology of the Cell·Eric SulpiceTatyana Merkulova-Rainon
Apr 10, 2010·Journal of the American College of Cardiology·Gareth J PadfieldNicholas L Mills
Apr 23, 2010·Cancer Metastasis Reviews·Scott A Bergfeld, Yves A DeClerck
Jan 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·James J KleinedlerTammy R Dugas
May 29, 2012·Nature Materials·Britta TrappmannWilhelm T S Huck
Jul 6, 2012·Trends in Biotechnology·Aaron TanAlexander M Seifalian
Oct 12, 2012·PloS One·Karolina Janeczek PortalskaJan de Boer
Jun 25, 2013·Nature Methods·Marina C PrewitzCarsten Werner
Oct 31, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Katharina M KatsarosWalter S Speidl
Oct 21, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tushar RainaJulian Gunn
Jul 3, 2015·Biological & Pharmaceutical Bulletin·Surim ParkBumseok Kim
Feb 18, 2016·Journal of Materials Science. Materials in Medicine·Kyung Seob LimJung Chaee Kang
Jul 20, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hyun-Kyung ChangJe-Yoel Cho
Nov 24, 2016·Science and Technology of Advanced Materials·Yuki ImaizumiYuji Miyahara
Oct 11, 2017·Journal of Tissue Engineering·Tarek M BedairDong Keun Han

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Citations

Apr 24, 2020·International Journal of Molecular Medicine·Zhixing FanCongxin Huang
Jan 26, 2021·Stem Cell Reviews and Reports·Hyun-Min Cho, Je-Yoel Cho
Mar 7, 2021·International Journal of Molecular Sciences·Rouven BerndtRené Rusch
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Xiaoli WangXiaoheng Liu
Apr 1, 2021·ACS Applied Materials & Interfaces·Jiaying ZhouYakai Feng

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Methods Mentioned

BETA
fluorescence microscopy
PCR
X-ray
scanning electron microscopy

Software Mentioned

CTan
LightLab
NRecon
Prism

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