Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response

The Annals of Thoracic Surgery
Martin WesterbergAnders Jeppsson

Abstract

Cardiotomy suction and autotransfusion of mediastinal shed blood may contribute to the inflammatory response after cardiac surgery. We compared inflammatory activation, myocardial injury, bleeding, and hemoglobin levels in patients undergoing coronary surgery with or without retransfusion of cardiotomy suction blood and mediastinal shed blood. Twenty-nine patients were included in a prospective randomized study. Cardiotomy suction blood and mediastinal shed blood were either retransfused or discarded. Plasma concentrations of the cytokines tumor necrosis factor-alpha and interleukin-6 and complement factor C3a were measured preoperatively and 10 minutes, 2 hours, and 24 hours after cardiopulmonary bypass. C-reactive protein, erythrocyte sedimentation rate, troponin-T, and hemoglobin levels were analyzed preoperatively, and 24 and 48 hours after cardiopulmonary bypass. Postoperative bleeding the first 12 hours was registered. Baseline data did not differ between the groups. Plasma concentrations of tumor necrosis factor-alpha, interleukin-6, and C3a increased after surgery in both groups but significantly less in the group without cardiotomy suction and autotransfusion. The peak delta values in the no-retransfusion group was 36%...Continue Reading

References

Oct 1, 1992·The Annals of Thoracic Surgery·N J JansenC R Wildevuur
Apr 1, 1995·The Annals of Thoracic Surgery·J de HaanW van Oeveren
Jan 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J de HaanT Ebels
Jul 1, 1998·The Annals of Thoracic Surgery·R F BrookerD A Stump
Nov 6, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·H T TevaearaiL K von Segesser
Jul 27, 1999·The Annals of Thoracic Surgery·W ReentsO Elert
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·H I Flom-HalvorsenR Oystese
Nov 18, 2000·The Annals of Thoracic Surgery·E H KincaidJ W Hammon
Nov 28, 2001·The Annals of Thoracic Surgery·J M Murkin
Feb 5, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D PaparellaE Young
Mar 21, 2002·Fundamental & Clinical Pharmacology·T MonsinjonM Fontaine

❮ Previous
Next ❯

Citations

Feb 22, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hansjörg JenniMario Stalder
Feb 14, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jakob GäbelAnders Jeppsson
Mar 24, 2006·Southern Medical Journal·George Ritter
Sep 5, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Joshua R PohlmannRobert H Bartlett
Oct 27, 2007·Journal of Cardiothoracic Surgery·Kelvin LauNeil Moat
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Rita KatznelsonJacek Karski
Jan 27, 2010·Mediators of Inflammation·Hunaid A VohraSunil K Ohri
Dec 26, 2015·Interactive Cardiovascular and Thoracic Surgery·Gerwin E EngelsAdrianus J de Vries
Nov 9, 2011·Scandinavian Cardiovascular Journal : SCJ·Atli EyjolfssonHenrik Bjursten
Aug 18, 2006·Scandinavian Cardiovascular Journal : SCJ·Christian A SkrabalAndreas Liebold
Feb 2, 2006·Scandinavian Cardiovascular Journal : SCJ·Obaid AljassimEva Berglin
Apr 29, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Melissa PedersenHanne B Ravn
Sep 18, 2013·Scandinavian Cardiovascular Journal : SCJ·Jakob GäbelAnders Jeppsson
Sep 12, 2009·Surgery·Mathieu LemaireJacob C Langer
Apr 14, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Henrik Jönsson
Jan 29, 2008·The Annals of Thoracic Surgery·Bertrand MarcheixLouis P Perrault
Apr 13, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Murtadha Al-KhaboriHilal Al-Sabti
Aug 23, 2006·Acta Anaesthesiologica Scandinavica·J K KoskenkariT I Ala-Kokko
Mar 28, 2006·The Annals of Thoracic Surgery·Anjo M DraaismaRobert A E Dion
Jul 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Christian A SkrabalAndreas Liebold
May 31, 2006·The Journal of Thoracic and Cardiovascular Surgery·Martin WesterbergAnders Jeppsson
Apr 27, 2010·The Annals of Thoracic Surgery·Sune DamgaardDaniel A Steinbrüchel
Jul 22, 2008·The Annals of Thoracic Surgery·Olivier FabreBrigitte Jude
Sep 23, 2008·The Annals of Thoracic Surgery·Munir BoodhwaniUNKNOWN Cardiotomy Investigators
Dec 3, 2014·The Annals of Thoracic Surgery·Wytze J VermeijdenAdrianus J de Vries
May 4, 2016·Acta Anaesthesiologica Scandinavica·J GäbelA Jeppsson
Jun 10, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Martin KarlssonAnders Jeppsson
Apr 15, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Allison Bechtel, Julie Huffmyer
Feb 23, 2013·Asian Cardiovascular & Thoracic Annals·Maria A PrietoGuillermo Reyes
Jun 29, 2010·Perfusion·Nathan CurtisSunil K Ohri
Jun 29, 2010·Perfusion·Vladimir SvitekFaraz Anjum
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christian A SkrabalAndreas Liebold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Martin WesterbergAnders Jeppsson
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Anita E JewellGraham Cooper
© 2022 Meta ULC. All rights reserved