PMID: 2017Sep 1, 1975

Coronary vascular and myocardial responses to carotid body stimulation in the dog

The American Journal of Physiology
I C EhrhartF J Haddy

Abstract

Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic acti...Continue Reading

Citations

Oct 1, 1976·Circulation Research·G Ross
Aug 20, 2015·Anesthesia and Analgesia·G J Crystal
Jun 5, 2020·Expert Opinion on Drug Discovery·Riccardo ZanniJorge Galvez
Mar 24, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Christina PapaemmanouilAndreas G Tzakos
Nov 10, 2020·Journal of Medical Internet Research·Ruth PlackettChristian von Wagner

Related Concepts

Diastolic Blood Pressure
Carbon Dioxide
Carotid Body
Structure of Carotid Sinus
Chemoreceptor Cells
Coronary Circulation
Canis familiaris
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Pulse Rate
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