PMID: 6218741Jan 15, 1983Paper

Coronary vascular reserve in left ventricular hypertrophy secondary to chronic aortic regurgitation

The American Journal of Cardiology
A D PichardR Gorlin

Abstract

Coronary vascular reserve was studied in 11 patients with severe chronic aortic regurgitation (AR). Nineteen patients with the chest pain syndrome and normal findings on cardiac catheterization served as control subjects. Resting coronary sinus flow and contrast-agent-induced hyperemia were measured by continuous thermodilution. Left ventricular (LV) dimensions and mass were obtained echocardiographically. All patients had normal coronary arteries. Resting coronary flow was increased and coronary reserve was decreased in patients with AR compared with the control subjects: 310 +/- 38 versus 121 +/- 13 ml/min and 56 +/- 9 versus 86 +/- 7.5%, respectively. The decrease in coronary vascular reserve correlated with the increase in LV mass (r = -0.86, p = 0.001) and LV wall thickness (r = -0.83, p = 0.002) and with the decrease in LV volume/mass ratio (r = 0.761, p = 0.007). There was no significant correlation between the decrease in coronary vascular reserve and LV volume (r = 0.255), LV peak wall stress (r = 0.292), LV systolic pressure (r = -0.495), aortic or LV diastolic pressure (r = 0.322 and -0.318, respectively), or aortic-LV diastolic gradient, nor with the voltage on the electrocardiogram (limb leads r = -0.60, precordial...Continue Reading

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Citations

Mar 25, 2000·Journal of Molecular and Cellular Cardiology·M P KingsburyD J Sheridan
May 31, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eugenia RaichlinNaveen L Pereira
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May 1, 1993·The American Journal of Cardiology·A ChauhanP Schofield
Oct 1, 1987·American Heart Journal·J VergariA S Iskandrian
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Apr 6, 2017·The International Journal of Cardiovascular Imaging·Ragab A MahfouzAshraf Dewedar
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Dec 8, 2017·Coronary Artery Disease·Takeshi NishiYoshio Kobayashi
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