Coronary vasoconstriction by endothelin-1 in anesthetized goats: role of endothelin receptors, nitric oxide and prostanoids

European Journal of Pharmacology
J L GarciaG Diéguez

Abstract

The role of endothelin ETA and ETB receptors as well as of nitric oxide (NO) and prostanoids in the effects of endothelin-1 on the coronary circulation was studied in anesthetized goats. Where blood flow in the left circumflex coronary artery (coronary blood flow) (electromagnetically measured), systemic arterial pressure, left ventricle pressure and d P/dt, and heart rate were recorded. Endothelin-1 (0.01-0.3 nmol), intracoronarily injected, produced marked, dose-dependent reductions in basal coronary blood flow, ranging from 5% for 0.01 nmol to 75% for 0.3 nmol; 0.1 and 0.3 nmol endothelin-1 also reduced systolic ventricle pressure and dP/dt. The effects of endothelin-1 on coronary blood flow were diminished during intracoronary infusion of BQ-123 (cyclo-(D-Asp-Pro-D-Val-Leu-D-Trp). specific antagonist for endothelin ETA receptors. 2-16 nmol/min) in a dose-dependent way, but not during the infusion of BQ-788 (N-[N-[N-[(2.6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-1-leucyl]-1- (methoxycarbonyl)-D-tryptophyl]-D-norleucine monosodium, specific antagonist for endothelin ETB receptors. 2-4 nmol/min). IRL 1620 (Suc-[Glu9, Ala11.15]endothelin-1-(8-21), specific agonist for endothelin ETB receptors. 0.01-0.3 nmol), intracoronarily i...Continue Reading

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Citations

Nov 26, 2003·European Journal of Pharmacology·Nuria FernándezGodofredo Diéguez
Mar 1, 2005·European Journal of Pharmacology·Angel Luis García-VillalónGodofredo Diéguez
Jul 4, 1998·European Journal of Pharmacology·N FernándezG Diéguez
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Francine G SmithAlp Sener
Jul 22, 1998·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·M Anbar
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Daphne MerkusWilliam M Chilian
Sep 5, 2009·Journal of Cardiovascular Pharmacology·Angel Luis García-VillalónGodofredo Diéguez
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Osamu YamaguchiYasuchika Takeishi
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Michel Lavallée, Eric Thorin
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D W SteppW M Chilian
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D MerkusW M Chilian

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