PMID: 3091131Jul 1, 1986Paper

Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4

British Journal of Pharmacology
P J Piper, A G Stewart

Abstract

Platelet-activating factor (Paf, 0.04-4.50 nmol) dose-dependently induced coronary vasoconstriction and decreased cardiac contractility in rat, isolated perfused hearts and concomitantly released leukotriene-like bioactivity into the cardiac effluent. Platelet-activating factor (0.9 nmol) induced an increase in 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), PGF2 alpha, PGE2 and thromboxane B2 (TXB2) measured by radioimmunoassay (RIA) of cardiac effluents following partial purification using C18 Sep-Paks. The leukotriene-like bioactivity released by Paf was identified as leukotriene C4 (LTC4) using a combination of isolation on reverse phase-h.p.l.c. (r.p.h.p.l.c.) and quantitation by RIA. In addition, LTB4 was also identified by r.p.h.p.l.c. and the levels, determined by RIA, were within the range having biological activity. The release of cyclo-oxygenase products by Paf was prevented by indomethacin (2.8 microM), markedly attenuated by diethylcarbamazine (7.7 mM) but unaffected by FPL 55712 (1.9 microM)-pretreatment. Furthermore, LTC4 (50 pmol) did not increase the release of the cyclo-oxygenase products measured. The release of LTB4 and LTC4 appeared to be unaffected by indomethacin pretreatment whereas diethylcarbamazine...Continue Reading

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Citations

Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·G L StahlA M Lefer
Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Oct 1, 1995·Biological Trace Element Research·A EvangelouB Arnoux
Feb 8, 2013·Current Heart Failure Reports·Paraskevi DetopoulouSmaragdi Antonopoulou
May 10, 1988·European Journal of Pharmacology·G L StahlA M Lefer
Oct 1, 1991·Prostaglandins·M Nakamura, Y S Bakhle
Apr 1, 1991·Trends in Cardiovascular Medicine·M R HollandS M Prescott
Nov 14, 2002·Biochemical Pharmacology·Yiqun Hui, Colin D Funk
May 14, 2003·Cellular Signalling·Sajal Chakraborti
Mar 1, 1997·Journal of Lipid Mediators and Cell Signalling·G FeuersteinS Vonhof
Aug 17, 1987·European Journal of Biochemistry·M Huber, D Keppler
May 1, 1987·Clinical and Experimental Pharmacology & Physiology·M R FennessyA G Stewart
Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Nov 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R RibeiroE V Tibiriçá
Jun 28, 2013·The Journal of Dermatology·Asuka YoshifukuTakuro Kanekura
Sep 11, 1995·Brain Research·L C PettigrewR A Yokel
Apr 1, 1989·Journal of Veterinary Internal Medicine·B Hansen
Mar 1, 1988·British Journal of Pharmacology·E NishiyeH Kuriyama
Mar 8, 2011·Experimental Biology and Medicine·Claudia PennaGiuseppe Alloatti
Sep 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P MentzH J Mest
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·I ViossatP Braquet
Jan 1, 1991·Annals of the New York Academy of Sciences·P J PiperD A Spencer

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