Coronary vasoconstriction produced by vasopressin in anesthetized goats. Role of vasopressin V1 and V2 receptors and nitric oxide

European Journal of Pharmacology
N FernándezG Diéguez

Abstract

To examine the role of vasopressin V1 and V2 receptors, nitric oxide and prostanoids in the coronary vascular effects of [Arg8]vasopressin, coronary blood flow was measured with an electromagnetic flow transducer placed around the left circumflex (23 goats) or anterior descending (11 goats) coronary artery and vasopressin (0.03-1 microg) was intracoronarily injected in 34 anesthetized, open-chest goats. Basal mean values for coronary blood flow, mean systemic arterial pressure and heart rate, were 34 +/- 2.38 ml/min, 89 +/- 3.34 mmHg and 80 +/- 3.06 beats/min, respectively. Vasopressin produced dose-dependent decreases in coronary blood flow and the maximal reduction of this flow, attained with 1 microg of vasopressin, was 14 +/- 1.49 ml/min (42 +/- 2.64% of basal flow) (P < 0.01). Desmopressin (0.03-1 microg; 8 goats) did not affect significantly coronary blood flow. The intracoronary infusion of the antagonist for vasopressin V1 receptors d(CH2)5Tyr (Me) arginine vasopressin (2 microg/min per kg, 6 animals) significantly diminished the effects of vasopressin on coronary blood flow (the effects of 1 microg of vasopressin were reduced by 28%, P < 0.05). The mixed antagonist for vasopressin V1 and V2 receptors desGly-d(CH2)5-D-T...Continue Reading

References

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Citations

Nov 26, 2003·European Journal of Pharmacology·Nuria FernándezGodofredo Diéguez
Jul 25, 2003·European Journal of Pharmacology·María Angeles MartínezGodofredo Diéguez
Feb 21, 2004·Critical Care : the Official Journal of the Critical Care Forum·Cheryl L HolmesJohn T Granton
Mar 14, 2014·Journal of Cardiovascular Pharmacology·Jean-Sébastien PelletierPo-Yin Cheung
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Khalid BenamarMartin W Adler
Oct 24, 2001·Anaesthesia and Intensive Care·P Forrest
Jan 22, 2003·Drugs·Martin W DunserWalter R Hasibeder
Nov 15, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chang Hyun Kang, Won Gon Kim
Aug 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arnaldo PinelliEdgardo Bonacina

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