Coronavirus Disease 2019: A Brief Review of the Clinical Manifestations and Pathogenesis to the Novel Management Approaches and Treatments

Frontiers in Oncology
Omid KooshkakiBehzad Baradaran

Abstract

The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) in China, which spread to the rest of the world, led the World Health Organization to classify it as a global pandemic. COVID-19 belongs to the Bettacoronavirus genus of the Coronaviridae family, and it mainly spreads through the respiratory tract. Studies have now confirmed a human-to-human transmission as the primary pathway of spread. COVID-19 patients with a history of diseases such as respiratory system diseases, immune deficiency, diabetes, cardiovascular disease, and cancer are prone to adverse events (admission to the intensive care unit requiring invasive ventilation or even death). The current focus has been on the development of novel therapeutics, including antivirals, monoclonal antibodies, and vaccines. However, although there is undoubtedly an urgent need to identify effective treatment options against infection with COVID-19, it is equally important to clarify management protocols for the other significant diseases from which these patients may suffer, including cancer. This review summarizes the current evidence regarding the epidemiology, pathogenesis, and management of patients with COVID...Continue Reading

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Citations

Apr 12, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mohit AgrawalP Sarat Chandra

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Methods Mentioned

BETA
bronchoalveolar
lavage
enzyme-linked immunosorbent assay
biopsy
ELISA
cesarean section
hysterectomy
glycosylation

Clinical Trials Mentioned

NCT04321421
NCT04306497
NCT04315298
NCT04317092
NCT04304313
NCT04307693
NCT04304053
NCT04292899
NCT04333355
NCT04332380

Software Mentioned

MEGA X
BLASTn

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