Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury

Clinical Kidney Journal
Raphaël KormannAbderrahim Oussalah

Abstract

Recent data have shown that severe acute respiratory syndrome coronavirus 2 can infect renal proximal tubular cells via Angiotensin Converting Enzyme 2 (ACE2) . Our objective was to determine whether Fanconi syndrome is a frequent clinical feature in coronavirus disease 2019 (COVID-19) patients. A retrospective cohort of 42 laboratory-confirmed COVID-19 patients without history of kidney disease hospitalized in University Hospital of Nancy was investigated. Patients were admitted to the intensive care unit (ICU) (n = 28) or the Medical department (n = 14) and were screened at least once for four markers of proximal tubulopathy. The mean (standard deviation) follow-up was 19.7 (±12.2) days. Of the patients, 75% (30/40) showed at least two proximal tubule abnormalities (incomplete Fanconi syndrome). The main disorders were proteinuria (88%, n = 35), renal phosphate leak defined by renal phosphate threshold/glomerular filtration rate (TmPi/GFR) <0.77 (55%, n = 22), hyperuricosuria (43%, n = 17) and normoglycaemic glycosuria (30%, n = 12). At the time of the first renal evaluation, ICU patients presented more frequent (96 versus 62%, P = 0.0095) and more severe (844 ± 343 versus 350 ± 221 mg/g, P = 0.0001) proteinuria, and a trend ...Continue Reading

References

Apr 21, 1998·Annals of Clinical Biochemistry·R B Payne
Feb 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·O L BIJVOET, C L MAJOOR
Apr 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chahrazed El HamelGuy Touchard
Aug 27, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Guillaume BolléeBertrand Knebelmann
Sep 17, 2015·Journal of the American Society of Nephrology : JASN·Michael B StokesVivette D D'Agati
Aug 4, 2016·BMC Nephrology·Rolando Claure-Del Granado, Ravindra L Mehta
Aug 31, 2016·Nature Microbiology·Man-Lung YeungKwok-Yung Yuen
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Warren L Kupin
Aug 3, 2017·International Journal of STD & AIDS·Nicholas A MedlandChristopher K Fairley
Jan 29, 2019·Annals of Internal Medicine·Nathan C Bahr, Sri G Yarlagadda
Jun 15, 2019·Annals of Intensive Care·Laurent PapazianHenri Faure
Jun 17, 2019·Advances in Chronic Kidney Disease·Leslie A Bruggeman
Jun 17, 2019·Advances in Chronic Kidney Disease·Narayan PrasadManas R Patel
Sep 14, 2019·KI Reports·Johanna TietäväinenJukka Mustonen
Mar 25, 2020·Kidney International·Saraladevi NaickerVivekanand Jha

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Citations

Nov 12, 2020·American Journal of Physiology. Endocrinology and Metabolism·Theo A T G van Kempen, Elisabeth Deixler
Oct 27, 2020·F1000Research·Holly Mabillard, John A Sayer
Mar 30, 2021·Frontiers in Physiology·Marie-Bénédicte Le StangNahid Tabibzadeh

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Methods Mentioned

BETA
biopsies
bronchoalveolar lavage
electrophoresis
biopsy

Software Mentioned

GraphPad Prism

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