Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen

Therapeutics and Clinical Risk Management
Mahtabalsadat MirjaliliAfsaneh Vazin

Abstract

The 2019 novel coronavirus disease (COVID-19) was first detected in Wuhan, Hubei Province, China, in late 2019. Since then, COVID-19 has spread to more than 200 countries in the world, and a global pandemic has been declared by the World Health Organization (WHO). At present, no vaccines or therapeutic regimens with proven efficacy are available for the management of COVID-19. Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, such as tocilizumab, have been recommended as potential treatment options in COVID-19. Transplant patients receiving immunosuppressant medications are at the highest risk of severe illness from COVID-19. At the same time, with regard to receiving polypharmacy and immunosuppressants, treatment options should be chosen with more attention in this population. Considering drug-drug interactions and adverse effects of medications used for the treatment of COVID-19, such as QT prolongation, the dose reduction of some immunosuppressants or avoidance is recommended in transplant recipients with COVID-19. Thus, this narrative review describes clinically important considerations about the treatment of COVID-19 and immunosuppressive regim...Continue Reading

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Citations

Mar 18, 2021·Indian Journal of Ophthalmology·Garima Singh, Umang Mathur
Mar 25, 2021·Transplantation Proceedings·Akanksha AryaKatherine A Belden
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Aug 6, 2021·International Immunopharmacology·Manica NegahdaripourAfsaneh Vazin
Aug 28, 2021·Journal of Clinical and Translational Hepatology·Parita Patel, Anjana Pillai

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