Coronavirus disease 2019 in chronic kidney disease

Clinical Kidney Journal
Luis D'MarcoJosé Luis Gorriz

Abstract

The clinical spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic infection to severe pneumonia with respiratory failure and even death. More severe cases with higher mortality have been reported in older patients and in those with chronic illness such as hypertension, diabetes or cardiovascular diseases. In this regard, patients with chronic kidney disease (CKD) have a higher rate of all-type infections and cardiovascular disease than the general population. A markedly altered immune system and immunosuppressed state may predispose CKD patients to infectious complications. Likewise, they have a state of chronic systemic inflammation that may increase their morbidity and mortality. In this review we discuss the chronic immunologic changes observed in CKD patients, the risk of COVID-19 infections and the clinical implications for and specific COVID-19 therapy in CKD patients. Indeed, the risk for severe COVID-19 is 3-fold higher in CKD than in non-CKD patients; CKD is 12-fold more frequent in intensive care unit than in non-hospitalized COVID-19 patients, and this ratio is higher than for diabetes or cardiovascular disease; and acute COVID-19 mortality is 15-25% for haemodialysis patients even when ...Continue Reading

Citations

Mar 7, 2021·International Urology and Nephrology·Chuou XuMin Han
Jun 3, 2021·Viruses·Belete A DesimmieKara S Willenburg
Jun 3, 2021·Medical Sciences : Open Access Journal·Christina BorchersRavi P Sahu

❮ Previous
Next ❯

Methods Mentioned

BETA
Infection
X-ray

Clinical Trials Mentioned

NCT04317092
NCT04288713
NCT04299724
NCT04276896
NCT04334980
NCT04283461
NCT04328285
NCT04330495
NCT04304053
NCT04318015

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.