Coronin 1c and F-actin Promote Metastasis of Breast Cancer

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jianqiang ShaoZunyi Wang

Abstract

BACKGROUND We studies the expression of Coronin 1c and F-actin protein in breast cancer and explored their relationship with breast cancer metastasis. MATERIAL AND METHODS A total of 210 breast cancer tissues and adjacent normal tissues were collected from January 2013 to December 2014. The expressions of Coronin 1c and F-actin were detected by immunohistochemistry and Western blotting. We analyzed the relationship between Coronin 1c and F-actin and clinical data of breast cancer. RESULTS The expressions of Coronin 1c and F-actin in breast cancer tissues were positively correlated (r=0.926, P<0.05) and were significantly higher than those in normal tissues (P<0.05). The Coronin 1c and F-actin expressions were not correlated with age, tumor size, ER expression, or PR expression in breast cancer patients (P>0.05), but were significantly correlated with HER-2 expression, histological grade, lymph node metastasis, molecular classification, and TNM (P<0.05). The expression of HER-2 in breast cancer tissues was positively correlated with the expression of Coronin 1c (r=0.706, P<0.05) and F-actin 1c, while F-actin protein in breast cancer tissues with lymph node metastasis was significantly higher than in those without lymph node meta...Continue Reading

Citations

Jul 17, 2020·Disease Markers·Xiaojing YangJie Fu
Oct 19, 2020·Cell Death & Disease·Florian WegwitzSteven A Johnsen

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