Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.

FEBS Letters
Yuewen ChenYu Chen

Abstract

Cytoskeletal remodeling is indispensable for the development and maintenance of neuronal structures and functions. However, the molecular machinery that controls the balance between actin polymerization and depolymerization during these processes is incompletely understood. Here, we report that coronin 2B, a conserved actin-binding protein, is concentrated at the tips of developing dendrites and that knockdown of coronin 2B inhibits the growth of dendrites. Importantly, coronin 2B interacts with actin and reduces the F-actin/G-actin ratio. Furthermore, the coiled-coil domain of coronin 2B is required for its oligomerization, thus confining coronin 2B to neurite tips. Our findings collectively suggest that coronin 2B is important for promoting dendrite outgrowth by limiting the speed of actin polymerization at growth cones.

References

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D MullinsT D Pollard
Sep 5, 2002·Nature Reviews. Neuroscience·Jorge Santos da Silva, Carlos G Dotti
Feb 28, 2006·Nature Cell Biology·Nelson A MedeirosPaul Forscher
Sep 2, 2006·The EMBO Journal·Simone Di GiovanniAlan I Faden
Oct 18, 2008·Sub-cellular Biochemistry·Meghal Gandhi, Bruce L Goode
May 14, 2010·Annual Review of Biophysics·Anders E Carlsson
Jun 15, 2013·Nature Reviews. Immunology·Jean PietersRajesh Jayachandran
Oct 30, 2013·Journal of Neurochemistry·Timothy M Gomez, Paul C Letourneau
Feb 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuewen ChenNancy Y Ip
Sep 3, 2014·Neuroscience Letters·Yunus Kasim TerziSukriye Ayter
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Federico ColomboJacopo Meldolesi
Dec 15, 2015·Cytoskeleton·Rashmi SrivastavaAmogh A Sahasrabuddhe
Sep 30, 2016·Molecular Biology of the Cell·Jonathan X ChiaTatyana M Svitkina
Dec 13, 2016·Journal of Molecular Biology·Olga S SokolovaBruce L Goode
Feb 22, 2017·Vitamins and Hormones·M MartorellaC D Deppmann
Nov 20, 2018·Frontiers in Cellular Neuroscience·Erin M Craig

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