Corosolic acid: antiangiogenic activity and safety of intravitreal injection in rats eyes

Documenta Ophthalmologica. Advances in Ophthalmology
Cibele Rodrigues ToledoArmando Silva-Cunha

Abstract

Investigate the potential application of corosolic acid (CA) in the treatment of diseases causing retinal neovascularization. CA cytotoxicity effect was evaluated in ARPE-19 cells by sulforhodamine B colorimetric method, and antiangiogenic activity was studied using chorioallantoic membrane (CAM) assay. An amount of 0.01 mL of CA formulations at 5, 10 and 25 µM was injected in the right eyes of Wistar rats, and the contralateral eyes received the vehicle to verify the safety of ophthalmic use. Electroretinography (ERG) was performed before, 7 and 15 days after CA administration. Animals were killed on the 15th day, and the histological analysis of retina was carried out under light microscopy. CA did not present cytotoxicity at concentrations below 35.5 μM after 48 h of treatment. The antiangiogenic activity was confirmed by CAM assay, since CA (range from 5 to 25 µM) induced a significant reduction in vascularity without any signs of toxicity. ERG recordings and histological evaluation did not show any signs of retinal toxicity. CA was effective in reducing vascularity in a CAM model and was found to be safe for potential ophthalmic use.

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Citations

Jul 6, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Mayara Rodrigues Brandão de PaivaArmando Silva-Cunha
Oct 6, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Lays Fernanda Nunes DouradoArmando da Silva Cunha
Jan 10, 2020·International Ophthalmology·Silvia BartollinoCiro Costagliola
Aug 29, 2020·Translational Vision Science & Technology·Carolina Nunes da SilvaArmando da Silva Cunha-Jr
Aug 6, 2020·International Journal of Molecular Sciences·Marisa PalazzoCiro Costagliola
Nov 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lays Fernanda Nunes DouradoArmando Silva-Cunha
Mar 25, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Mayara Rodrigues Brandão de PaivaSilvia Ligório Fialho
May 27, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Cibele Rodrigues ToledoArmando Silva-Cunha
Sep 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cibele Rodrigues ToledoArmando Silva-Cunha

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