Corpora amylacea in prostatectomy tissue and associations with molecular, histological, and lifestyle factors

The Prostate
Natalie DuPreTransdisciplinary Prostate Cancer Partnership(ToPCaP)

Abstract

Corpora amylacea are amyloid bodies commonly found adjacent to damaged prostate epithelium. Little is known about their formation or function. The current study sought to characterize corpora amylacea in prostate tissue and to describe their relationship with clinical, histological, molecular, and lifestyle factors, especially with chronic inflammation which is associated with aggressive disease. We studied a cohort of 355 men with prostate cancer and tissue specimens from the Health Professionals Follow-Up Study. Pathologists examined H&E slides and undertook a standardized review for histologic data and inflammation. Trained observers counted corpora amylacea within the benign and predominately tumor areas. Immunohistochemistry biomarkers were available from tissue microarrays. We used multivariable logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) to assess associations of chronic inflammation, clinical, histological, molecular, and lifestyle factors with the presence of corpora amylacea. Corpora amylacea were present in benign tissue area for 298 men (84%). Specimens with moderate-to-severe chronic inflammation were more likely to have corpora amylacea in benign regions (OR = 5.4 95%CI 1.9, ...Continue Reading

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Citations

Feb 10, 2019·Journal of Clinical Medicine·Kazutoshi FujitaNorio Nonomura
Apr 10, 2020·The Prostate·Watchareepohn PalangmonthipKenneth A Iczkowski
Jun 18, 2020·Nature Reviews. Cancer·Johann S de BonoAndrea Alimonti
Oct 21, 2020·Cancers·Maddison ArcherNatasha Kyprianou
Dec 22, 2020·Diagnostic Cytopathology·Haresh Mani, Brant G Wang
Jul 6, 2019·Cell Calcium·Julien AnractThierry Capiod
Oct 12, 2021·Ageing Research Reviews·Marta RibaCarme Pelegrí

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