PMID: 11342975May 9, 2001Paper

Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation

The Journal of Urology
D N SimopoulosA Nehra

Abstract

The pathophysiology of diabetes mellitus induced erectile dysfunction is poorly understood. In patients with diffuse venous leakage structural changes in the corpora cavernosa have correlated with failure of the veno-occlusive mechanism. Three-dimensional (D) micro computerized tomography (CT) has proved to be an important imaging technique for the intact kidney, heart, liver and bone. We examined control and diabetic rabbit penises by 3-D micro CT and quantified any structural changes. Male white New Zealand rabbits were treated with alloxan to induce diabetes or used as normal controls. Via aortic access at laparotomy the penile vascular tree was vasodilated with papaverine and perfused with radiopaque silicone rubber. X-ray micro CT was then performed at 21 microm. resolution and images were analyzed in 3-D using custom software. Nine diabetic rabbits with blood glucose greater than 400 mg./dl. and 9 control animals were used for micro CT analysis. Significant decreases (p <0.05) were observed in the mean sinusoidal and vascular volume fraction plus or minus standard error of mean of the corpus cavernosum in the diabetic (323.7 +/- 43.1 mm.3 and 37.9 +/- 2.0%, respectively) and control (510.1 +/- 47.4 mm.3 and 53.1 +/- 3.80%...Continue Reading

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Citations

Nov 7, 2007·Investigative Radiology·Soenke H BartlingFabian Kiessling
Sep 20, 2006·International Journal of Clinical Practice·D L BrowneM H Cummings
Sep 7, 2014·Current Diabetes Reports·Konstantinos Hatzimouratidis, Dimitrios Hatzichristou
Jul 1, 2012·Translational Stroke Research·Bohua XieGuo-Yuan Yang
May 15, 2007·The Journal of Sexual Medicine·Linda VignozziMario Maggi
May 10, 2006·The Journal of Sexual Medicine·Abdulmaged M Traish, André T Guay
Dec 21, 2010·BJU International·Marcelo Abidu-FigueiredoFrancisco J B Sampaio
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Craig L DuvallRobert E Guldberg
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Yun ChenRun Wang

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