Corpus callosotomy for drug-resistant spasms associated with tuberous sclerosis complex

Epilepsy & Behavior : E&B
Tohru OkanishiHideo Enoki

Abstract

Corpus callosotomy (CC) has recently been adopted for the treatment of drug-resistant epileptic spasms and tonic spasms. In the present study, we investigated CC outcomes among patients with drug-resistant epileptic spasms or tonic spasms associated with tuberous sclerosis complex (TSC). We retrospectively collected data from seven patients (3 women, 4 men) with diagnosed TSC and who were treated using CC at Seirei Hamamatsu General Hospital in Japan. All patients had experienced drug-resistant epileptic spasms (<3 s of muscular contraction) or tonic spasms (>3 s) prior to CC, which were confirmed via video-electroencephalogram monitoring. All patients exhibited multiple bilateral cortical tubers on brain magnetic resonance imaging. The main seizure types were epileptic spasms in four, tonic spasms in one, and both seizure types in two patients. Patients underwent total CC between the ages of 25 months and 21.5 years. Additional resection or disconnection was performed in two patients. The follow-up period after CC ranged between 9 months and 3.5 years. Three patients achieved remission from spasms following CC alone. Two other patients became free from spasms several months after CC but required an additional focus disconnecti...Continue Reading

Citations

Jun 15, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jeffrey M TreiberJonathan Roth
Aug 22, 2021·CNS Drugs·Rima NabboutPaolo Curatolo
Mar 24, 2020·Epilepsy & Behavior : E&B·Ayataka FujimotoHideo Enoki

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