Corpus Callosotomy for Intractable Epilepsy Revisited: The Children's Hospital of Michigan Series

Journal of Child Neurology
Aimee F LuatSandeep Sood

Abstract

Corpus callosotomy is a palliative procedure performed to reduce the severity of drug-resistant epilepsy. The authors assessed its efficacy on different seizure types in 20 subjects (age range 5-19 years); 8 with active vagus nerve stimulator. Fifteen had complete callosotomy, 3 had anterior 2/3, and 2 had anterior 2/3 followed later by complete callosotomy. Ten had endoscopic approach. In all, 65% had ≥ 50% reduction of generalized seizures leading to falls (atonic, tonic, myoclonic); 35% became seizure-free (follow-up period: 6 months to 9 years; mean 3 years). Seizure outcome distribution was better for generalized than for partial seizures ( P = .003). Endoscopic approach was as effective as transcranial approach. Seven subjects who failed vagus nerve stimulator therapy responded with ≥50% seizure reduction. Corpus callosotomy is an effective treatment for intractable generalized epilepsy leading to falls with significant seizure reduction or even elimination of seizures, in the majority of children.

References

Dec 28, 1999·Epilepsia·J M PinardO Dulac
Sep 3, 2005·Seizure : the Journal of the British Epilepsy Association·Shang-Yeong KwanChun-Hing Yiu
Jun 10, 2008·Epilepsy & Behavior : E&B·Ali A Asadi-PooyaMichael R Sperling
Sep 19, 2008·Seizure : the Journal of the British Epilepsy Association·Shigeki SunagaHidenori Sugano
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ajay KumarHarry T Chugani
Oct 17, 2012·Seizure : the Journal of the British Epilepsy Association·Guido LancmanTheodore H Schwartz
Mar 19, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·M RajpurkarS Sood
Aug 28, 2014·Pediatric Neurology·Mohammed IlyasHarry Chugani
Sep 26, 2015·Journal of Neurosurgery. Pediatrics·Sandeep SoodSteven D Ham
May 31, 2016·Epilepsia·David GrahamDeepak Gill
Sep 10, 2016·Journal of Neurosurgery. Pediatrics·Sandeep SoodAimee Luat

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Citations

Feb 27, 2019·Current Neurology and Neuroscience Reports·Sean T HwangSimona V Proteasa
Aug 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Keisuke UedaAimee F Luat
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Sebastian Rademacher, Britta J Eickholt
Apr 14, 2020·International Journal of General Medicine·Muhamad Thohar ArifinJacob Bunyamin
Jun 13, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Vincent C YeGeorge M Ibrahim
Jul 22, 2020·World Neurosurgery·Claudia M Kuzan-FischerCaitlin E Hoffman
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Takumi MitsuhashiEishi Asano
Apr 20, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Indar Kumar SharawatLesa Dawman
Mar 12, 2018·Neurología : publicación oficial de la Sociedad Española de Neurología·O Fernández-ConcepciónC Vásquez-Ham

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Methods Mentioned

BETA
surgical resections
dissection

Software Mentioned

SPSS

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