Corpus callosum damage predicts disability progression and cognitive dysfunction in primary-progressive MS after five years.

Human Brain Mapping
Benedetta BodiniO Ciccarelli

Abstract

We aim to identify specific areas of white matter (WM) and grey matter (GM), which predict disability progression and cognitive dysfunction after five years in patients with primary-progressive multiple sclerosis (PPMS). Thirty-two patients with early PPMS were assessed at baseline and after five years on the Expanded Disability Status Scale (EDSS), and EDSS step-changes were calculated. At year five, a subgroup of 25 patients and 31 healthy controls underwent a neuropsychological assessment. Baseline imaging consisted of dual-echo (proton density and T2-weighted), T1-weighted volumetric, and diffusion tensor imaging. Fractional anisotropy (FA) maps were created, and fed into tract-based spatial statistics. To compensate for the potential bias introduced by WM lesions, the T1 volumes underwent a lesion-filling procedure before entering a voxel-based morphometry protocol. To investigate whether FA and GM volume predicted EDSS step-changes over five years and neuropsychological tests scores at five years, voxelwise linear regression analyses were performed. Lower FA in the splenium of the corpus callosum (CC) predicted a greater progression of disability over the follow-up. Lower FA along the entire CC predicted worse verbal memo...Continue Reading

References

Dec 20, 1965·JAMA : the Journal of the American Medical Association·J E BogenP J Vogel
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Dec 31, 1997·Mayo Clinic Proceedings·D M WingerchukB G Weinshenker
Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
Jun 14, 2000·Annals of Neurology·A J ThompsonW I McDonald
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Sep 5, 2001·Nature Reviews. Neuroscience·R L Buckner, M E Wheeler
Jun 8, 2002·Annual Review of Neuroscience·Richard A Andersen, Christopher A Buneo
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·P GarrardD Playford
Jul 24, 2002·Brain : a Journal of Neurology·David H MillerAlan J Thompson
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael D RuggRichard N A Henson
Jul 3, 2004·Journal of Computer Assisted Tomography·Osamu AbeKuni Ohtomo
Aug 26, 2004·Multiple Sclerosis : Clinical and Laboratory Research·Bernard D CoombsJack H Simon
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Apr 23, 2005·Human Brain Mapping·Bradley R BuchsbaumKaren Faith Berman
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Aug 3, 2005·Nature Reviews. Neuroscience·Michael S Gazzaniga
Dec 29, 2005·Neurology·Helen TremlettVirginia Devonshire
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Nov 30, 2006·Human Brain Mapping·Hae-Jeong ParkJong Doo Lee
Jun 21, 2008·Lancet Neurology·Rohit BakshiMassimo Filippi
Jul 29, 2008·Annals of Neurology·Elizabeth FisherRichard A Rudick
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Nov 26, 2008·NeuroImage·S D RoosendaalF Barkhof
Dec 11, 2008·Human Brain Mapping·Sarlota MesarosMassimo Filippi
Feb 10, 2010·Multiple Sclerosis : Clinical and Laboratory Research·A OzturkD S Reich
Mar 13, 2010·Annals of Neurology·Velandai SrikanthDavid C Reutens
May 19, 2010·Brain Pathology·Tomasz DziedzicWolfgang Brück
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardClaudia A M Wheeler-Kingshott
Oct 30, 2010·Annals of Neurology·Jeroen J G GeurtsPaul van der Valk
Apr 27, 2011·Current Opinion in Neurology·Dawn W Langdon

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Citations

Dec 18, 2013·PloS One·Carmen TurXavier Montalban
Dec 29, 2013·AJR. American Journal of Roentgenology·Fernanda C Rueda-LopesEmerson L Gasparetto
May 18, 2013·AJNR. American Journal of Neuroradiology·A BlaschekB Ertl-Wagner
Sep 14, 2014·Seminars in Ultrasound, CT, and MR·Christopher G Filippi, Keith A Cauley
Feb 24, 2016·Journal of Autism and Developmental Disorders·V M VoganM J Taylor
Nov 4, 2015·Nature Reviews. Neurology·Christian EnzingerUNKNOWN MAGNIMS study group
May 22, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Silvana L CostaNancy D Chiaravalloti
Apr 1, 2017·Current Opinion in Neurology·Céline LouapreBruno Stankoff
Nov 24, 2019·Neurology. Neuroimmunology and Neuroinflammation·James M Stankiewicz, Howard L Weiner
Mar 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PetraccaM Inglese
Dec 12, 2018·Neural Regeneration Research·Sourajit M MustafiYu-Chien Wu
Jul 5, 2013·Current Opinion in Neurology·Andreas Kleinschmidt, Patrik Vuilleumier
Dec 28, 2018·Brain and Behavior·Marcin KolasaMarja-Liisa Sumelahti
Mar 4, 2020·Neurology. Neuroimmunology and Neuroinflammation·Svetlana BezukladovaLaura Airas
Nov 22, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael PlattenTobias Granberg
Feb 13, 2021·Neuropsychiatric Disease and Treatment·Elizabeth S Gromisch, Zaenab Dhari
May 8, 2021·Brain Communications·Mia WinterMaxime Chamberland
May 24, 2021·BMC Medical Imaging·Thomaz R MostardeiroKiaran P McGee
Aug 14, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Olga MarchesiMassimo Filippi

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