Corpus callosum in patients with obsessive-compulsive disorder: diffusion-tensor imaging study

Radiology
Y SaitoT Kinoshita

Abstract

To prospectively examine microstructural white matter abnormalities in the corpus callosum (CC) of patients with obsessive-compulsive disorder (OCD), as compared with control subjects, and to investigate the relationship between diffusion-tensor (DT) imaging measures of the CC region and clinical symptoms of OCD. Institutional review board approval was obtained, and each participant--or the participant's parent(s)--provided written informed consent. Sixteen patients with OCD (seven male, nine female; mean age, 28.7 years +/- 9.8 [standard deviation]) and 16 matched healthy volunteers (control subjects) (seven male, nine female; mean age, 29.9 years +/- 9.0) were examined. Mean diffusivity and fractional anisotropy (FA) were measured in five subdivisions of the CC. The paired t test was performed to compare the mean diffusivity or the FA in CC regions between the patients with OCD and the control subjects. There were no significant differences (rostrum, P = .15; genu, P = .88; rostral body, P = .12; isthmus, P = .77; splenium, P = .88) in mean diffusivity between the patients with OCD and the healthy volunteers. A significant reduction in FA was observed in the rostrum of the CC in patients with OCD compared with the rostral FA ...Continue Reading

References

Jun 1, 1989·Archives of General Psychiatry·S E SwedoJ L Rapoport
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·M C de LacosteE D Ross
Jan 1, 1984·Experimental Brain Research·H Barbas, D N Pandya
Jan 1, 1983·Experimental Brain Research·B Seltzer, D N Pandya
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·D H Zald, S W Kim
Jun 1, 1996·International Clinical Psychopharmacology·M M WeissmanP J Wickramaratne
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·D H Zald, S W Kim
Apr 10, 1999·Archives of General Psychiatry·K O LimA Pfefferbaum
Sep 15, 2000·The Psychiatric Clinics of North America·E Horwath, M M Weissman
Feb 1, 2003·Clinical Psychology Review·Scott Greisberg, Dean McKay
Jul 3, 2004·Journal of Computer Assisted Tomography·Osamu AbeKuni Ohtomo
Aug 5, 2004·Neuropsychobiology·Gaku OkugawaToshihiko Kinoshita
Sep 25, 2004·Journal of Clinical Psychology·Darin D DoughertyMichael A Jenike
Jul 6, 2005·Archives of General Psychiatry·Philip R SzeszkoKelvin O Lim
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·K NobuharaT Kinoshita

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Citations

Oct 27, 2009·European Archives of Psychiatry and Clinical Neuroscience·Myong-Wuk ChonJun Soo Kwon
Jun 12, 2013·Psychiatry Research·Timothy SilkAlasdair Vance
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patricia GrunerPhilip R Szeszko
Sep 23, 2010·Topics in Magnetic Resonance Imaging : TMRI·Leonardo F FontenelleChristos Pantelis
Jan 6, 2009·Current Opinion in Psychiatry·Cristian DamsaJoanna Moussally
Dec 2, 2010·Journal of Psychiatry & Neuroscience : JPN·Emre BoraMurat Yücel
Apr 27, 2013·AJR. American Journal of Roentgenology·Efsun UrgerJames M Provenzale
Jun 24, 2009·Radiology·Tsyh-Jyi HsiehWei-Chen Lin
Mar 31, 2012·Current Psychiatry Reports·Elliot AylingNic van der Wee
Feb 5, 2013·Psychiatry Research·Jamie D FeusnerAlex D Leow
Mar 5, 2013·Psychiatry Research·Katherine C LopezJay N Giedd
Oct 20, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·M Di PaolaG Spalletta
Jun 19, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·M Di PaolaG Spalletta
Dec 6, 2011·Trends in Cognitive Sciences·Mohammed R Milad, Scott L Rauch
Nov 22, 2011·Journal of Psychiatric Research·Kathrin KochRalf G M Schlösser
Oct 23, 2010·Journal of Psychiatric Research·Takashi NakamaeKenji Fukui
Dec 30, 2014·Biology of Mood & Anxiety Disorders·Isabelle M RossoScott L Rauch
Mar 18, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S De SantisS Capuani
Feb 11, 2012·Depression and Anxiety·Rajan Nishanth JayarajanChannapatna R Chandrashekar
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Roberta BiundoAngelo Antonini
Nov 2, 2013·Neuroscience and Biobehavioral Reviews·Federica PirasGianfranco Spalletta
Sep 8, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco BenedettiEnrico Smeraldi
Apr 4, 2014·Journal of Psychiatric Research·Kathrin KochMichael Zaudig
Dec 17, 2014·Pediatric Neurology·Chaw-Liang ChangNan-Chang Chiu
Nov 3, 2015·Acta Neuropsychiatrica·Tue HartmannPoul Videbech
Apr 17, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Maria Paula MazieroMarcelo Q Hoexter
Jun 8, 2021·Brain Communications·Fabrizio PirasGianfranco Spalletta
Feb 12, 2021·Journal of Behavioral Addictions·Małgorzata DrapsMateusz Gola

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