PMID: 11923595Mar 30, 2002Paper

Corpus callosum, pons, and cortical white matter in alcoholic women

Alcoholism, Clinical and Experimental Research
A PfefferbaumE V Sullivan

Abstract

To measure the effect of alcohol abuse on white matter brain macrostructure in women with alcoholism and to determine whether observed abnormalities interact with age. Quantitative measures of corpus callosum area, cortical white matter volume, and pons volume were derived from magnetic resonance imaging scans obtained from 34 women with DSM-III-R alcoholism (aged 28-64, mean 41 years) and 35 healthy women (aged 22-65, mean 42 years). Transverse relaxation time of the pons was also obtained. No significant group differences in any brain measures were observed. However, in alcoholics greater length of sobriety was associated with more cortical white matter, and higher lifetime levels of alcohol consumption were associated with smaller volumes and prolonged transverse relaxation time in the pons. Despite a lack of overall deficits in white matter macrostructural size in alcoholic women, certain white matter structures showed alcohol exposure vulnerability whereas others showed evidence of recovery with abstinence.

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Citations

Apr 19, 2005·Psychopharmacology·Edith V Sullivan, Adolf Pfefferbaum
Sep 18, 2007·Neuropsychology Review·Marlene Oscar-Berman, Ksenija Marinković
Nov 15, 2003·Alcohol·Patrick J MulhollandMark A Prendergast
Jan 30, 2004·Neurobiology of Aging·Edith V SullivanAdolf Pfefferbaum
Jan 5, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Andreas KonradChristoph Fehr
Nov 8, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Sergei MechtcheriakovJosef Marksteiner
Mar 25, 2011·Neuropsychiatric Disease and Treatment·Marlene Oscar-Berman, Janet Song
Sep 14, 2013·Psychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Sep 29, 2009·Biological Psychiatry·Edith V SullivanAdolf Pfefferbaum
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Adolf PfefferbaumEdith V Sullivan
Sep 18, 2008·Alcoholism, Clinical and Experimental Research·Adolf PfefferbaumEdith V Sullivan
Feb 28, 2008·Alcoholism, Clinical and Experimental Research·Krista Lisdahl MedinaSusan F Tapert
Jun 26, 2012·Alcoholism, Clinical and Experimental Research·Susan Mosher RuizGordon J Harris
Apr 1, 2014·Brain and Behavior·Mollie A MonnigKent E Hutchison
Jan 25, 2005·Psychiatry Research·Courtnay W BloomerDieter J Meyerhoff
Aug 30, 2005·Biological Psychiatry·Adolf PfefferbaumEdith V Sullivan
Jun 21, 2005·Neurobiology of Aging·Adolf PfefferbaumEdith V Sullivan
Aug 12, 2014·Neuroscience and Biobehavioral Reviews·Anne Lise PitelHélène Beaunieux
Apr 23, 2019·Journal of Neuroscience Research·Michael FritzNatalie M Zahr
Sep 29, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Irina FilippiFrédéric Limosin

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