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Correcting a SHAPE-directed RNA structure by a mutate-map-rescue approach

bioRxiv

Jan 22, 2014

Siqi TianRhiju Das

Abstract

The three-dimensional conformations of non-coding RNAs underpin their biochemical functions but have largely eluded experimental characterization. Here, we report that integrating a classic mutation/rescue strategy with high-throughput chemical mapping enables rapid RNA structure infere...read more

Mentioned in this Paper

RNA, Untranslated
Three-dimensional
Primer Extension
Macromolecular Alteration
Hydroxyl group
Oligonucleotide Primers
Ribosomes
Nucleotides
Structure
Base Pairing
Paper Details
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Correcting a SHAPE-directed RNA structure by a mutate-map-rescue approach

bioRxiv

Jan 22, 2014

Siqi TianRhiju Das

PMID: 990001966

DOI: 10.1101/001966

Abstract

The three-dimensional conformations of non-coding RNAs underpin their biochemical functions but have largely eluded experimental characterization. Here, we report that integrating a classic mutation/rescue strategy with high-throughput chemical mapping enables rapid RNA structure infere...read more

Mentioned in this Paper

RNA, Untranslated
Three-dimensional
Primer Extension
Macromolecular Alteration
Hydroxyl group
Oligonucleotide Primers
Ribosomes
Nucleotides
Structure
Base Pairing
Paper Details
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  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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