Correction factors after having neglected the first exponential in the estimation of chromium-51 EDTA clearance: a reappraisal

Annals of Nuclear Medicine
Carlos De SadeleerH R Ham

Abstract

The aim of the present work was to evaluate two classical formulae allowing the correction for having neglected the first exponential in the slope-intercept method used for the determination of EDTA clearance, namely the Chantler's linear correction formula (CH) and the Bröchner-Mortensen's quadratic correction formula (BM). First, a comparison study was performed with the two correction formulae, in order to predict the behavior of the calculated clearance, for various levels of renal function. Second, using data obtained from 47 adult patients with normal renal function, the results obtained with the two correction formulae have been compared to the reference technique, namely the biexponential fit. The results of the comparison study indicated that for clearance values lower than 120 ml/min, the results obtained using CH were systematically lower than those of BM, whereas for clearance values between 120 and 140 ml/min, the reverse was observed. The differences however, never exceeded 8 ml/min. The results were quite different when the clearance was higher than 140 ml/min, when the difference between CH and BM results increased rapidly, and the BM provided values systematically lower than CH. The clinical study showed that, ...Continue Reading

References

Apr 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-MortensenJ Christoffersen
Aug 1, 1972·Archives of Disease in Childhood·C Chantler, T M Barratt

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Citations

May 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Amy PiepszHamphrey Ham
Aug 23, 2018·Journal of the Chinese Medical Association : JCMA·Arash MalakianSolmaz Heidari

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