Correction for Susceptibility Distortions Increases the Performance of Arterial Spin Labeling in Patients with Cerebrovascular Disease

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Vince I MadaiJan Sobesky

Abstract

Arterial spin labeling (ASL) is an MRI technique to measure cerebral blood flow (CBF) without the need of exogenous contrast agents and is thus a promising alternative to the clinical standard dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion imaging. Latest international guidelines encourage its application in the clinical setting. However, susceptibility-induced image distortions impair ASL with fast readout modules (eg Echo Planar Imaging, EPI; gradient and spin echo, GRASE). In the present study, we investigated the benefit of a distortion correction for ASL compared to DSC. A pulsed ASL (PASL) sequence combined with a 3D-GRASE readout at multiple inflow times (multi-TI) was used and was corrected for susceptibility distortions using a FMRIB Software Library (FSL) implemented tool TOPUP. We performed qualitative (three expert raters) and quantitative (volume of interest [VOI]-based) comparisons of ASL and DSC imaging in 13 patients with chronic steno-occlusive disease. In the qualitative analysis, distortion correction of the images led to a strong increase in diagnostic precision of ASL compared to DSC in the anterior cerebral artery (ACA) perfusion territory, where the susceptibility artifact was most pron...Continue Reading

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Citations

Jan 10, 2018·Acta Radiologica·Inger HavsteenAnders F Christensen
Jan 23, 2019·Journal of Magnetic Resonance Imaging : JMRI·Zahra ShirzadiUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 28, 2020·The Neuroradiology Journal·Peter StoeterPamela Bido
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Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christian R MeixnerArmin M Nagel
Dec 9, 2021·Brain and Behavior·Vita CardinaleGabriele Ende

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