Correction of hemorrhagic shock-induced liver hypoxia with whole blood, Ringer's solution or with hetastarch.

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
H J MäkisaloK A Höckerstedt

Abstract

Liver oxygenation was studied with hemorrhagic hypotension and corrected using whole blood, a synthetic colloid (hydroxyethyl starch or hetastarch, HES; mol. wt. 120,000), or a crystalloid solution. Measurements were performed directly by recording pig liver tissue oxygen tension with an implanted silicone elastomer (Silastic) tube, and indirectly by calculating blood oxygen contributions. The direct method seems fairly reliable and accurately reflects different levels of bleeding and shock and their correction. Liver tissue oxygen tension (PlO2) may thus be used as an indicator of central organ response to shock management. PlO2 decreased during bleeding from 33.5 +/- 0.5 to 16.0 +/- 0.5 torr, and normalized rapidly after retransfusion. The baseline values were significantly exceeded after hetastarch infusion but were never reached with Ringer's solution. The correction of liver oxygen consumption was less complete after crystalloid infusion as well. On the other hand, the difference in liver oxygenation was less marked after crystalloid infusion and retransfusion, which restored perfusion to the baseline. The total amount of Ringer's solution needed to keep the animals hemodynamically stable during the 2-h follow-up period wa...Continue Reading

References

Mar 1, 1976·Clinical Science and Molecular Medicine·J YudkinB Slack
Apr 1, 1976·The Journal of Surgical Research·F LittooyG F Sheldon
Nov 1, 1989·Critical Care Medicine·H J MäkisaloK A Höckerstedt
Jan 1, 1987·International Anesthesiology Clinics·G Gammage
Jan 1, 1985·Acta Anaesthesiologica Scandinavica. Supplementum·H Haljamäe
Oct 5, 1972·The New England Journal of Medicine·H PontoppidanE Lowenstein
Jan 25, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K MessmerM Kessler
Aug 1, 1973·American Journal of Surgery·T M MaxwellT K Hunt
Jan 1, 1972·Surgery·J Ninikoski, T K Hunt
May 1, 1970·Archives of Surgery·G NunesW Margaretten
Dec 1, 1981·Critical Care Medicine·V K PuriL White
Jul 1, 1984·Journal of Clinical Pharmacology·K KorttilaM A Mattila
Jan 1, 1982·International Anesthesiology Clinics·D R Jobes, J Gallagher
Feb 1, 1982·The Surgical Clinics of North America·J W Holcroft
Apr 1, 1964·Archives of Surgery·T SHIRESS LIGHTFOOT

❮ Previous
Next ❯

Citations

Oct 1, 1990·Acta Anaesthesiologica Scandinavica·T RandellK Höckerstedt
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Paul E Marik
Dec 1, 1999·Critical Care Medicine·M TallgrenL Lindgren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.