PMID: 11318844Apr 25, 2001Paper

Correction of hyperglycaemia reduces insulin resistance and serum soluble E-selectin levels in patients with Type 2 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
K MatsumotoS Miyake

Abstract

To investigate the effects of glycaemic control on insulin sensitivity and serum concentrations of soluble vascular cell adhesion molecule (sVCAM)-1 and E-selectin (sE-selectin) in patients with Type 2 diabetes mellitus. To examine whether reductions in serum adhesion molecule levels correlate with improvement in insulin resistance. A total of 54 patients with Type 2 diabetes were treated for 4 weeks with either diet alone, sulphonylurea or insulin. Fasting glucose, insulin sensitivity, lipids, sVCAM-1, and sE-selectin levels were measured before and after treatment. All treatment modalities successfully corrected hyperglycemia. Reductions in blood glucose levels resulted in improvement in insulin sensitivity (diet KITT 2.40 +/- 0.26-3.09 +/- 0.36, P < 0.01; sulphonylurea 2.24 +/- 0.16-2.94 +/- 0.18, P < 0.01; insulin 1.68 +/- 0.27-2.16 +/- 0.22%/min, P < 0.05), and decrease in sE-selectin levels (diet 88.4 +/- 14.9-66.2 +/- 10.8, P < 0.05; sulphonylurea 85.1 +/- 11.6-59.8 +/- 7.8, P < 0.01; insulin 84.4 +/- 8.7-66.8 +/- 7.4 ng/ml, P < 0.01), but no change in sVCAM-1 levels. There was a significant correlation between the degree of decrease in sE-selectin levels and improvement in insulin sensitivity (r = -0.38, P < 0.01). Corr...Continue Reading

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Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Jun 11, 2011·The Journal of Biological Chemistry·Te-Chuan ChenCheng-Nan Chen
Mar 12, 2015·High Altitude Medicine & Biology·Tan YueLi Min
Dec 17, 2009·Metabolism: Clinical and Experimental·Kazunari MatsumotoYukitaka Ueki
Jan 18, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Larissa Avilés-SantaPhilip Raskin
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·S T KnudsenL M Rasmussen

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