Correction of metabolic acidosis and its effect on albumin in chronic hemodialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
J P Brady, J A Hasbargen

Abstract

Serum albumin concentration has been strongly associated with risk of death in hemodialysis patients, with mortality increasing as albumin decreases. Metabolic acidosis stimulates protein catabolism and decreases protein synthesis. A study was undertaken to investigate the effect of increasing predialysis serum bicarbonate (HCO3) concentrations on the nutrition of hemodialysis patients as measured by albumin and total lymphocyte count (TLC). Metabolic acidosis was defined as a predialysis serum bicarbonate concentration of < or = 18 mEq/L. Thirty-six hemodialysis patients were enrolled in the study. Each had been stable on hemodialysis for > or = 3 months and each had a mean serum bicarbonate concentration of < or = 18 mEq/L on predialysis monthly laboratory values during the preceding 3 months. The subjects were randomized into 2 groups. The first group consisted of 18 control subjects who were dialyzed on a standard bicarbonate bath of 35 mEq/L. The second group consisted of 18 experimental patients who were dialyzed on a bicarbonate bath of 40 mEq/L. Subjects in the experimental group who had predialysis serum bicarbonate concentrations less than 22 mEq/L after 2 weeks on the higher bicarbonate bath were additionally supplem...Continue Reading

Citations

Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mariano FerianiUNKNOWN Study Group
Aug 13, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wei Chen, Matthew K Abramowitz
May 28, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Nov 26, 2015·Seminars in Dialysis·David Tovbin, Richard A Sherman
Sep 13, 2003·Kidney International·Berthil H C M T PrinsenMonique G M De Sain-Van Der Velden
Oct 9, 2003·Kidney International. Supplement·George A Kaysen
Dec 14, 1999·Kidney International·P GoldwasserR H Barth
Nov 13, 2002·Kidney International·Trinh B PiferEric W Young
Jan 14, 2000·Kidney International. Supplement·J D LoudenT H Goodship
Feb 12, 2004·Kidney International. Supplement·Rajnish MehrotraMarsha Wolfson
Feb 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ezio MovilliGiovanni C Cancarini
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W E Mitch, S R Price
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S AhmadC R Blagg
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maurizio BossolaGiovanna Luciani
Oct 6, 2004·Seminars in Dialysis·Cheuk-Chun Szeto, Kai-Ming Chow
Apr 21, 2006·Hemodialysis International·Khaldoun SoudanAshwini R Sehgal
Aug 3, 2000·Seminars in Dialysis·F J Gennari
Aug 3, 2000·Seminars in Dialysis·J P Brady, J A Hasbargen
Nov 10, 2000·Advances in Renal Replacement Therapy·J M Burkart
Jan 27, 2007·The Cochrane Database of Systematic Reviews·P RoderickC Tomson
Jan 16, 2010·Journal of the American Society of Nephrology : JASN·Allon N Friedman, Stephen Z Fadem
Apr 4, 2019·Seminars in Dialysis·John A SargentF John Gennari
Feb 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Matthew K AbramowitzThomas H Hostetter
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·N Cano
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Maurizio MuscaritoliFilippo Rossi Fanelli
Nov 25, 2016·Journal of the American Society of Nephrology : JASN·Matthew K Abramowitz
Oct 17, 2002·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Cathy VeroveRaymond Azar
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey A Kraut, Ira Kurtz
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J UribarriG Yan
Jul 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

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