Correction of the effects of source, source strength, and soft-tissue thickness on spine dual-photon absorptiometry measurements

Calcified Tissue International
B Dawson-HughesL Sadowski

Abstract

Dual photon absorptiometry measurements of the spine are subject to drift associated with source, source strength, and truncal thickness. This study was conducted to determine the extent to which this drift in bone mineral density (BMD) measurements can be improved by analysis of scans with a new software version, 08C, and by applying external standard or phantom corrections to scans analyzed with the older version, 08B. A phantom, consisting of human lumbar vertebrae embedded in acrylic, and five clear acrylic plates to simulate a soft-tissue thickness range of 15.2-27.9 cm, was measured on a Lunar Radiation Corp DP3 scanner over the life of a 153-gadolinium (Gd) source and scans analyzed with software versions 08B and 08C. Phantom BMD was lower with 08C at both high [0.012 +/- 0.002 (SEM) g/cm2, P less than 0.001] and low (0.027 +/- 0.003 g/cm2, P less than 0.001) count rates than with 08B. Phantom BMD of scans analyzed with 08B increased with increasing source age and the source strength-related increment increased significantly as acrylic thickness increased (P = 0.014). When the same scans were analyzed with 08C, the thickness-related effect was corrected whereas a small (0.011 g/cm2/year) source-strength effect persisted....Continue Reading

References

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Citations

Apr 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KleerekoperP Wilson
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D P KielJ J Anderson
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
Dec 1, 1996·Calcified Tissue International·E A KrallB Dawson-Hughes
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E A KrallR I Garcia
May 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H RicoM Alvarez de Buergo
Oct 1, 1990·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D O SlosmanJ P Bonjour
Apr 1, 1990·Calcified Tissue International·B Dawson-Hughes, G E Dallal
Sep 1, 1991·Calcified Tissue International·J Johnson, B Dawson-Hughes
Oct 1, 1991·Calcified Tissue International·P Lakatos, I Krasznai
Sep 27, 1990·The New England Journal of Medicine·B Dawson-HughesS Tannenbaum
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