Correlated effects of selection for immunity in White Leghorn chicken lines on natural antibodies and specific antibody responses to KLH and M. butyricum

BMC Genetics
G MinozziMarie-Helen Pinard-van der Laan

Abstract

The effect of selection for three general immune response traits on primary antibody responses (Ab) to Mycobacterium butyricum or keyhole limpet hemocyanin (KLH) was studied in four experimental lines of White Leghorn chicken. Birds underwent 12 generations of selection for one of three different general immune criteria; high antibody response to Newcastle disease virus 3 weeks after vaccination (ND3), high cell-mediated immune response, using the wing web response to phytohemglutinin (PHA) and high phagocytic activity, measured as carbone clearance (CC). Line ND3-L was selected on ND3, line PHA-L was selected on PHA, and line CC-L on CC, but all lines were measured for all three traits. The fourth line was a contemporary random bred control maintained throughout the selection experiment. Principal component analysis was used to distinguish clusters based on the overall set of immune measures. In the KLH immunised group, no differences were present between lines for natural antibodies binding to KLH and LPS, and, lines ND3-L and PHA-L had higher titers to LTA and anti-Gal titers measured before the immunisation protocol. The measure of ND3 was correlated positively with LPS titers measured post KLH immunisation and with the dif...Continue Reading

References

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Citations

Nov 4, 2011·Journal of Applied Genetics·Maria SiwekMarek Bednarczyk
Aug 11, 2011·PloS One·Laurence FloriClaire Rogel-Gaillard
Jun 8, 2012·Domestic Animal Endocrinology·P Mormede, E Terenina
Sep 5, 2017·Environmental Technology·Moritz GoldLinda Strande

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Methods Mentioned

BETA
PCA
ELISA

Software Mentioned

SPAD
SAS

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