Correlated random walks of human embryonic stem cells in vitro

Physical Biology
L E WadkinN G Parker


We perform a detailed analysis of the migratory motion of human embryonic stem cells in two-dimensions, both when isolated and in close proximity to another cell, recorded with time-lapse microscopic imaging. We show that isolated cells tend to perform an unusual locally anisotropic walk, moving backwards and forwards along a preferred local direction correlated over a timescale of around 50 min and aligned with the axis of the cell elongation. Increasing elongation of the cell shape is associated with increased instantaneous migration speed. We also show that two cells in close proximity tend to move in the same direction, with the average separation of [Formula: see text]m or less and the correlation length of around 25 μm, a typical cell diameter. These results can be used as a basis for the mathematical modelling of the formation of clonal hESC colonies.


Feb 1, 1979·Biophysical Journal·R L Hall, S C Peterson
Oct 20, 1977·Journal of Mathematical Biology·R L Hall
Oct 1, 1970·Biophysical Journal·M H Gail, C W Boone
Feb 1, 1993·Current Opinion in Neurobiology·M E Hatten
Feb 8, 2002·Developmental Cell·Clemens M FranzAnne J Ridley
Jun 12, 2002·Molecular Biology of the Cell·Joseph Ostashevsky
Apr 2, 2003·Cell Biology Education·Bruce Alberts, UNKNOWN National Academies
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Mar 31, 2007·Circulation Research·Laurent LamaliceJacques Huot
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Holger KressAlexander Rohrbach
Apr 23, 2008·Journal of the Royal Society, Interface·Edward A CodlingSimon Benhamou
May 8, 2008·Nature Reviews. Microbiology·Ken F Jarrell, Mark J McBride
Jun 12, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Satoshi Kurosaka, Anna Kashina
Apr 23, 2009·PloS One·Leonard Bosgraaf, Peter J M Van Haastert
Jul 16, 2009·Nature Reviews. Molecular Cell Biology·Ryan J PetrieKenneth M Yamada
May 1, 2003·FEMS Microbiology Ecology·Greg M Barbara, James G Mitchell
Nov 17, 2009·Developmental Biology·Andy Aman, Tatjana Piotrowski
Mar 13, 2010·PloS One·Alka A PotdarPeter T Cummings
Apr 27, 2010·Human Molecular Genetics·Maria C N MarchettoFred H Gage
Aug 17, 2010·PLoS Computational Biology·Peter J M Van Haastert
Apr 12, 2011·Nature Methods·Guokai ChenJames A Thomson
Oct 1, 2011·Circulation Research·Vincent F M Segers, Richard T Lee
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Krishanu SahaRudolf Jaenisch
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Aug 3, 2012·Nature Cell Biology·Peter FriedlJeffrey E Segall
Dec 6, 2012·Nature Communications·Takamichi MiyazakiEihachiro Kawase
Aug 6, 2013·Annual Review of Cell and Developmental Biology·Gaudenz DanuserAlex Mogilner
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stanislav BurovAaron R Dinner
May 8, 2014·Development·Germán ReigMiguel L Concha
Jul 25, 2014·PLoS Computational Biology·Alessandro AttanasiMassimiliano Viale
Aug 26, 2014·Nature Reviews. Molecular Cell Biology·Matthias Krause, Alexis Gautreau
Jul 4, 2015·Cell Stem Cell·Alan Trounson, Courtney McDonald
Sep 19, 2015·Scientific Reports·Smruti M PhadnisRenee A Reijo Pera
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Xiangming Guan
Jan 20, 2016·The Journal of Cell Biology·Elena Scarpa, Roberto Mayor
Dec 3, 2016·Nature Reviews. Cancer·Colin D PaulKonstantinos Konstantopoulos
Dec 1, 2017·BMC Bioinformatics·Curtis T RuedenKevin W Eliceiri
Jan 20, 2018·Physical Review. E·François Detcheverry

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Oct 28, 2019·Scientific Reports·L E WadkinA Shukurov
Jun 5, 2020·Scientific Reports·Joaquim Fort
Aug 18, 2020·SN Applied Sciences·L E WadkinN G Parker
Nov 28, 2019·Scientific Reports·Sirio Orozco-FuentesNicholas G Parker

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