Correlates of B-type natriuretic peptide and 6-min walk in heart failure patients

International Journal of Cardiology
Jochem HogenhuisDirk J van Veldhuisen

Abstract

B-type natriuretic peptide (BNP) and 6-min walk test (6MWT) are both related to the severity and prognosis in chronic heart failure (CHF), but may reflect different aspects of CHF. We related BNP and 6MWT to left ventricular ejection fraction (LVEF), New York Heart Association functional class (NYHA), and two indices of quality of life (physical subscales): the Minnesota Living with Heart Failure Questionnaire (MLwHFQph) and the RAND-36ph. Plasma BNP and 6MWT were measured at discharge in 229 patients who had been admitted for CHF. LVEF and NYHA were determined, and patients completed the MLwHFQ and RAND-36 questionnaires. BNP was weakly correlated to LVEF (r=-0.29, P<0.01) and NYHA (r=0.20, P<0.01), but not to MLwHFQph and RAND-36ph. On the other hand, 6MWT is related to MLwHFQph (r=-0.23, P<0.01), RAND-36ph (r=0.52, P<0.01), and NYHA (r=-0.46, P<0.01), but not to LVEF (r=-0.15, P=0.05). There is also no correlation between BNP and 6MWT (r=-0.01, P=0.87). The present data show that BNP and 6MWT represent different aspects of the clinical syndrome of CHF. The outcomes of this study suggest that BNP plasma levels are more related to cardiac function, while 6MWT reflects functional capacity and quality of life.

References

Sep 13, 1990·The New England Journal of Medicine·M MukoyamaH Imura
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·R J BainW A Littler
Jan 1, 1985·Journal of Chronic Diseases·G H GuyattS O Pugsley
Sep 10, 1998·Journal of Cardiovascular Pharmacology·M MetraL Dei Cas
Dec 19, 1998·Journal of the American College of Cardiology·A LuchnerH Schunkert
Jan 6, 2001·Journal of Cardiac Failure·P BettencourtM Cerqueira-Gomes
Oct 2, 2001·American Heart Journal·C DemersUNKNOWN RESOLVD Pilot Study Investigators
Oct 31, 2002·Metabolism: Clinical and Experimental·Wen-Sheng HuangHong-Da Chang
Nov 7, 2002·International Journal of Cardiology·Geert TjeerdsmaDirk J van Veldhuisen
Feb 1, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stacey J WieczorekAlan H B Wu
Mar 20, 2003·European Journal of Heart Failure·P JourdainD Duboc
Dec 17, 2003·European Journal of Heart Failure·Luisa Zanolla, Piero Zardini
Feb 28, 2004·European Journal of Heart Failure·Alan H B Wu, Andrew Smith

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Citations

Jan 21, 2010·Age and Ageing·Jardi HuzenDirk J van Veldhuisen
Aug 9, 2012·Future Cardiology·Danielle HarakeSteven E Lipshultz
Jul 20, 2010·Scandinavian Cardiovascular Journal : SCJ·Birgitta Blakstad NilssonIngebjørg Seljeflot
Feb 5, 2008·International Journal of Cardiology·Yumi ShiinaIssei Komuro
Sep 16, 2009·Congestive Heart Failure·Paul J MillsBarry H Greenberg
Feb 8, 2008·The American Heart Hospital Journal·Florim CuculiPaul Erne
Dec 3, 2009·Journal of Cardiopulmonary Rehabilitation and Prevention·Leonidas V AthanasopoulosDennis V Cokkinos
May 18, 2016·Journal of Cardiovascular Medicine·Pier P BassareoGiuseppe Mercuro
Dec 24, 2010·Journal of Cardiovascular Medicine·Alessandro SalustriWael A Al Mahmeed
Oct 19, 2016·Journal of Cardiovascular Medicine·Pier P BassareoGiuseppe Mercuro
Aug 15, 2017·Tropical Medicine & International Health : TM & IH·Mayara C ChambelaRoberto M Saraiva

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