Correlates of knee bone marrow lesions in younger adults

Arthritis Research & Therapy
Benny AntonyChanghai Ding

Abstract

Subchondral bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain and structural progression in knee OA. However, little is known about clinical significance and determinants of BMLs of the knee joint in younger adults. We aimed to describe the prevalence and environmental (physical activity), structural (cartilage defects, meniscal lesions) and clinical (pain, stiffness, physical dysfunction) correlates of BMLs in younger adults and to determine whether cholesterol levels measured 5 years prior were associated with current BMLs in young adults. Subjects broadly representative of the Australian young adult population (n = 328, aged 31-41 years, female 48.7 %) underwent T1- and proton density-weighted fat-suppressed magnetic resonance imaging (MRI) in their dominant knee. BMLs, cartilage defects, meniscal lesions and cartilage volume were measured. Knee pain was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and physical activity was measured by the International Physical Activity Questionnaire (IPAQ). Cholesterol levels including high-density lipoprotein (HDL) were assessed 5 years prior to MRI. The overall prevalence of BML was 17 ...Continue Reading

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Citations

May 19, 2017·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Julien OliveJean-Philippe Germain
Jan 11, 2017·Current Opinion in Rheumatology·Alice CourtiesFrancis Berenbaum
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Sep 15, 2016·Arthritis Research & Therapy·Benny AntonyChanghai Ding
Jun 20, 2020·The Journal of International Medical Research·Kazuhiko Hashimoto, Masao Akagi
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May 6, 2021·Journal of Hip Preservation Surgery·Maria A MunschW Kelton Vasileff
Aug 23, 2021·BMC Musculoskeletal Disorders·Ylva B EricssonKristina E Akesson

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