Correlates of placental infection with cytomegalovirus, parvovirus B19 or human herpes virus 7

Journal of Medical Virology
S S W ChowW D Rawlinson

Abstract

Vertical transmission of viruses is an important cause of morbidity in the fetus and neonate. Placental viral infection indicates risk of vertical transmission, but not always transmission to, or disease of the fetus. Specimens from mothers and babies from three groups-two prospective and one retrospective cohort-were tested for pathogens of teratogenic potential using multiplex PCR. Placental infection was present in 13% of the 105 samples collected. Assessment of the prospective cohorts showed cytomegalovirus (CMV) detected in 4% of placentae from unselected women, parvovirus B19 in 1% and Ureaplasma parvum in 1% of placentae. In a retrospective cohort of women at high risk of transmitting congenital infection due to seroconversion during pregnancy, miscarriage or stillbirth, CMV was detected in 64% and human herpes virus type 7 in 9% of placentae. Of 14 PCR-positive placentae, two were associated with the birth of a living symptomatic infant, two with stillbirth, one with miscarriage, and two with elective terminations of pregnancy. Directed laboratory assessment of women at high risk of transmitting congenital infection, on the basis of clinical or laboratory markers, is important for accurate diagnosis of adverse outcomes ...Continue Reading

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Citations

Jul 10, 2013·Virology Journal·Maja D Kaspersen, Per Höllsberg
Dec 31, 2008·PloS One·Mariantonietta Di StefanoJosè Ramòn Fiore
Jan 31, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jonathan HowardWilliam Rawlinson
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Mar 27, 2012·Fetal and Pediatric Pathology·Mana TaweevisitPaul Scott Thorner
Nov 9, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gabriela Mafra de OliveiraRoberta Maia de Castro Romanelli

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